HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: MUC1 (P15941)
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
Gene: MUC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	16427018
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1255
+	Hs
		554348 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00
+	Hs
		369607 ESR1_HUMAN (1-595): 0: 599: 100.00		MDC1_HUMAN (3-737): 1.48e-23: 110: 11.44
+	Hs
		370417 ESR1_HUMAN (1-595): 0: 599: 100.00		TARA_HUMAN (36-1064): 2.31e-23: 110: 8.69
+	Hs
		369612 ESR1_HUMAN (1-595): 0: 599: 100.00		NCOA6_HUMAN (10-1050): 3.47e-16: 86.7: 9.70
+	Hs
		370263 ESR1_HUMAN (1-595): 0: 599: 100.00		MINT_HUMAN (22-1062): 3.99e-14: 80.1: 9.50
+	Hs
		146131 ESR1_HUMAN (1-595): 0: 599: 100.00		ARI1A_HUMAN (9-962): 3.38e-11: 70.2: 10.06
+	Hs
		370040 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2C_HUMAN (3-610): 1.39e-10: 68.3: 12.67
+	Hs
		370728 ESR1_HUMAN (1-595): 0: 599: 100.00		SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41
+	Hs
		152573 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2D_HUMAN (572-1064): 9.35e-09: 62.4: 12.35
+	Hs
		848264 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HCFC1_HUMAN (7-1107): 6.45e-29: 128: 11.01
+	Hs
		1270066 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PCLO_HUMAN (315-1124): 1.46e-24: 114: 11.36
+	Hs
		1056909 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MDC1_HUMAN (3-737): 1.48e-23: 110: 11.44
+	Hs
		1269591 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TARA_HUMAN (36-1064): 2.31e-23: 110: 8.69
+	Hs
		1057780 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NCOA6_HUMAN (10-1050): 3.47e-16: 86.7: 9.70
+	Hs
		1243831 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KMT2C_HUMAN (3-610): 1.39e-10: 68.3: 12.67
+	Hs
		1269948 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41
+	Hs
		1269667 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MUC5B_HUMAN (203-1090): 2.97e-09: 64: 10.14
+	Hs
		152674 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KMT2D_HUMAN (572-1064): 9.35e-09: 62.4: 12.35
+	Hs
		1269843 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		YM012_HUMAN (863-1145): 6.41e-09: 62.1: 11.23
+	Hs
		587169 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		NCOA6_HUMAN (10-1050): 3.47e-16: 86.7: 9.70