Protein: Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase)

Gene: Q8MSW0, IleRS
Organism: Drosophila melanogaster
Interactions: 91
UniProt ID: Q8MSW0

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004822 - isoleucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

58088

A1ZBE9
Methionine--tRNA ligase, cytoplasmic

2

12

High-throughput

0.737

High

53134

A1Z7K8
AaRS-interacting multifunctional protein 1

2

6

High-throughput

0.571

High

704364

SYEP
Bifunctional glutamate/proline--tRNA ligase

2

13

High-throughput

0.571

High

1264111

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

2

11

High-throughput

0.571

High

1321471

SYRC
Probable arginine--tRNA ligase, cytoplasmic

2

2

High-throughput

0.571

High

1321482

SYQ
Probable glutamine--tRNA ligase

2

5

High-throughput

0.571

High

852193

COPB
Coatomer subunit beta

2

2

High-throughput

0.521

High

118952

M9NFI9
Neurabin-1

1

2

High-throughput

0.445

High

356796

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

5

High-throughput

0.445

High

437990

PYR1
Multifunctional protein r

1

4

High-throughput

0.445

High

654284

DDX6
ATP-dependent RNA helicase me31b

1

1

High-throughput

0.445

High

726374

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

782731

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

2

High-throughput

0.445

High

823769

SQH
Myosin regulatory light chain sqh

1

1

High-throughput

0.445

High

852942

ACTZ
Actin-related protein 1

1

2

High-throughput

0.445

High

874984

PRS4
26S proteasome regulatory subunit 4

1

4

High-throughput

0.445

High

875230

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.445

High

911739

POLO
Serine/threonine-protein kinase polo

1

3

High-throughput

0.445

High

1057333

ARL2
ADP-ribosylation factor-like protein 2

1

1

High-throughput

0.445

High

1069741

Q0E931
GTP-binding protein 1

1

14

High-throughput

0.445

High

1070094

Q0E9E2
Pyruvate carboxylase

1

2

High-throughput

0.445

High

1173913

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

5

High-throughput

0.445

High

1265723

Q7K3H0
LD28067p

1

2

High-throughput

0.445

High

1321430

Q8SY39
ATP-dependent RNA helicase DDX54

1

3

High-throughput

0.445

High

1321433

Q8T4G5
AFG3 like matrix AAA peptidase subunit 2, isoform A

1

2

High-throughput

0.445

High

1321437

Q9V3V6
26S proteasome regulatory complex subunit p50

1

10

High-throughput

0.445

High

1321438

Q9V405
26S proteasome regulatory subunit 6B

1

3

High-throughput

0.445

High

1321441

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.445

High

1321446

Q9VAX8
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.445

High

1321447

DDX18
Probable ATP-dependent RNA helicase pitchoune

1

1

High-throughput

0.445

High

1321453

ATD3A
ATPase family AAA domain-containing protein 3A homolog

1

10

High-throughput

0.445

High

1321455

Q9VI53
LD44267p

1

1

High-throughput

0.445

High

1321456

DDX47
ATP-dependent RNA helicase DDX47

1

2

High-throughput

0.445

High

1321466

AIMP2
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

2

High-throughput

0.445

High

1321472

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

2

High-throughput

0.445

High

1321473

Q9VXR5
ATP-binding cassette sub-family F member 2

1

1

High-throughput

0.445

High

1321474

RENT1
Regulator of nonsense transcripts 1 homolog

1

2

High-throughput

0.445

High

1321475

Q9VZ88
AT07585p

1

5

High-throughput

0.445

High

1321477

Q9W0E4
Aminopeptidase

1

1

High-throughput

0.445

High

1321480

Q9W414
Regulatory particle triple-A ATPase 4

1

3

High-throughput

0.445

High

1321452

Q9VEV3
Tetratricopeptide repeat protein 1

1

7

High-throughput

0.437

High

1321461

GOLP3
Golgi phosphoprotein 3 homolog sauron

1

1

High-throughput

0.437

High

909863

PFKA
ATP-dependent 6-phosphofructokinase

1

0

High-throughput

0.426

High

1059153

ROP
Protein ROP

1

0

High-throughput

0.426

High

1175995

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.426

High

1321431

Q8SY53
GH11935p

1

0

High-throughput

0.426

High

1321434

Q8T8W3
AT21416p

1

0

High-throughput

0.426

High

1321435

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.426

High

1321442

Q9V455
Importin subunit alpha

1

0

High-throughput

0.426

High

1321444

Q9VAH7
N-terminal kinase-like protein

1

0

High-throughput

0.426

High

1321445

Q9VAW3
glutamine--fructose-6-phosphate transaminase

1

0

High-throughput

0.426

High

1321457

RAGP1
Ran GTPase-activating protein

1

0

High-throughput

0.426

High

55442

A1Z9E3
Elongation factor Tu

1

11

High-throughput

0.407

High

55783

A1Z9K0
Uncharacterized protein, isoform B

1

2

High-throughput

0.407

High

263383

PENG
Protein penguin

1

1

High-throughput

0.407

High

1234095

SARM1
NAD(+) hydrolase sarm1

1

1

High-throughput

0.407

High

1263206

Q7JXU4
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.407

High

1321432

ENA
Protein enabled

1

2

High-throughput

0.407

High

1321439

NOG1
Nucleolar GTP-binding protein 1

1

7

High-throughput

0.407

High

1321449

Q9VEH0
Aluminum tubes, isoform A

1

6

High-throughput

0.407

High

1321450

FLNA
Filamin-A

1

2

High-throughput

0.407

High

1321458

NFS1
Cysteine desulfurase, mitochondrial

1

2

High-throughput

0.407

High

1321459

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.407

High

1321463

Q9VQL7
Fatty acid synthase

1

3

High-throughput

0.407

High

1321467

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.407

High

1321468

RS10B
Small ribosomal subunit protein eS10B

1

2

High-throughput

0.407

High

1070312

Q0IGU0
IP21556p

1

0

High-throughput

0.257

Low

360549

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.232

Low

473612

RAS1
Ras-like protein 1

1

0

High-throughput

0.232

Low

715116

CLH
Clathrin heavy chain

1

0

High-throughput

0.232

Low

786374

2ABA
Protein phosphatase PP2A 55 kDa regulatory subunit

1

0

High-throughput

0.232

Low

834852

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.232

Low

1237002

Q6NP72
GEO09659p1

1

0

High-throughput

0.232

Low

1264022

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.232

Low

1268334

DYM
Dymeclin

1

0

High-throughput

0.232

Low

1321436

Q95WY3
Nucleolar protein 56

1

0

High-throughput

0.232

Low

1321440

API5
Apoptosis inhibitor 5 homolog

1

0

High-throughput

0.232

Low

1321443

Q9V9Q4
LD43819p

1

0

High-throughput

0.232

Low

1321448

Q9VDK7
Signal recognition particle subunit SRP72

1

0

High-throughput

0.232

Low

1321451

Q9VEP0
Regulatory protein zeste

1

0

High-throughput

0.232

Low

1321454

IPO9
Importin-9

1

0

High-throughput

0.232

Low

1321460

Q9VM57
Septin interacting protein 2, isoform A

1

0

High-throughput

0.232

Low

1321462

Q9VQI5
Interferon-related developmental regulator 1

1

0

High-throughput

0.232

Low

1321464

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.232

Low

1321465

FRL
Formin-like protein

1

0

High-throughput

0.232

Low

1321469

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

0

High-throughput

0.232

Low

1321470

Q9VXK5
Putative rRNA methyltransferase

1

0

High-throughput

0.232

Low

1321476

Q9VZU8
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.232

Low

1321478

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

1321479

Q9W1H8
acetyl-CoA C-acyltransferase

1

0

High-throughput

0.232

Low

1321481

Q9XZ53
dolichyl-diphosphooligosaccharide--protein glycotransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025