Protein: SYIC
Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)

Gene: SYIC, ILS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 118
UniProt ID: P09436

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004822 - isoleucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

481840

SSB1
Ribosome-associated molecular chaperone SSB1

4

7

Small-scale

0.666

High

481893

SSB2
Ribosome-associated molecular chaperone SSB2

3

7

Small-scale

0.624

High

460296

SYV
Valine--tRNA ligase, mitochondrial

1

6

Small-scale

0.618

High

481924

GET3
ATPase GET3

2

0

High-throughput

0.595

High

481881

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

1

High-throughput

0.588

High

481899

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

392049

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.571

High

481886

SSZ1
Ribosome-associated complex subunit SSZ1

2

4

Small-scale

0.571

High

477484

MYO1
Myosin-1

1

2

Small-scale

0.552

High

481839

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

481883

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.536

High

481927

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.536

High

481846

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.493

High

449044

CALM
Calmodulin

1

1

High-throughput

0.489

High

458974

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

High-throughput

0.489

High

481852

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.489

High

481872

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

High-throughput

0.489

High

481918

PML1
Pre-mRNA leakage protein 1

1

1

High-throughput

0.489

High

365529

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

367655

ENO1
Enolase 1

1

2

High-throughput

0.479

High

367861

ENO2
Enolase 2

1

2

High-throughput

0.479

High

416066

SYTC
Threonine--tRNA ligase, cytoplasmic

1

10

Small-scale

0.479

High

434709

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

435680

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

441617

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

454781

RS19A
Small ribosomal subunit protein eS19A

1

1

Small-scale

0.479

High

481835

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

481837

IPB2
Protease B inhibitor 2

1

1

High-throughput

0.479

High

481847

KCY
Uridylate kinase

1

1

High-throughput

0.479

High

481850

EF3A
Elongation factor 3A

1

1

Small-scale

0.479

High

481854

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

481856

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

481857

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

481859

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

481863

MLS1
Malate synthase 1

1

2

High-throughput

0.479

High

481864

HS104
Heat shock protein 104

1

6

High-throughput

0.479

High

481867

HOG1
Mitogen-activated protein kinase HOG1

1

6

High-throughput

0.479

High

481869

ZUO1
Zuotin

1

6

Small-scale

0.479

High

481871

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

481873

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

481878

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

1

High-throughput

0.479

High

481880

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.479

High

481882

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

481888

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

481890

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

481892

GDI1
Rab GDP-dissociation inhibitor

1

1

High-throughput

0.479

High

481895

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

High-throughput

0.479

High

481900

ARC1
tRNA-aminoacylation cofactor ARC1

1

7

Small-scale

0.479

High

481911

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

481914

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

481920

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

481922

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

481926

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.479

High

481897

COPB
Coatomer subunit beta

1

3

High-throughput

0.470

High

481907

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.460

High

358939

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.458

High

368385

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

368554

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

416345

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

433357

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

439199

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

481841

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

481843

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

481855

TKT1
Transketolase 1

1

0

High-throughput

0.458

High

481891

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

481902

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

481909

PROA
Gamma-glutamyl phosphate reductase

1

0

High-throughput

0.458

High

481928

KCS1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.458

High

394129

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.445

High

481836

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

481838

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

481845

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.445

High

481848

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

481858

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

481870

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

481874

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

481894

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.445

High

481896

DJP1
DnaJ-like protein 1

1

5

High-throughput

0.445

High

481916

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.445

High

481925

SMT3
Ubiquitin-like protein SMT3

1

3

High-throughput

0.439

High

481929

CMR1
DNA damage-binding protein CMR1

1

8

High-throughput

0.439

High

470435

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.437

High

481842

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

481849

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.437

High

481853

PYRC
Dihydroorotase

1

3

High-throughput

0.437

High

481861

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

481866

APE2
Aminopeptidase 2, mitochondrial

1

1

High-throughput

0.437

High

481877

PDX3
Pyridoxamine 5'-phosphate oxidase

1

1

High-throughput

0.437

High

481885

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.437

High

481889

MPT5
Suppressor protein MPT5

1

1

High-throughput

0.437

High

481908

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.437

High

481912

ESP1
Separin

1

1

High-throughput

0.437

High

481913

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.437

High

481915

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

481917

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

481921

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

481923

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.437

High

481851

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

481901

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

481904

DPH4
Diphthamide biosynthesis protein 4

1

4

High-throughput

0.407

High

481910

PTA1
Pre-tRNA-processing protein PTA1

2

0

High-throughput

0.319

High

481876

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

481919

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

481865

TFC1
Transcription factor tau 95 kDa subunit

1

0

High-throughput

0.269

Low

481868

RPN12
26S proteasome regulatory subunit RPN12

1

0

High-throughput

0.269

Low

360928

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

367467

TRPE
Anthranilate synthase component 1

1

0

Small-scale

0.249

Low

481844

AROF
Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited

1

0

High-throughput

0.249

Low

481860

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.249

Low

481862

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

481875

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

0

High-throughput

0.249

Low

481879

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

481884

ECM29
Proteasome component ECM29

1

0

High-throughput

0.249

Low

481887

SDO1L
Restriction of telomere capping protein 3

1

0

High-throughput

0.249

Low

481898

EMP47
Protein EMP47

1

0

Small-scale

0.249

Low

481903

HOC1
Putative glycosyltransferase HOC1

1

0

Small-scale

0.249

Low

481905

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.249

Low

481906

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025