HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PRDX2 (P32119)
Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)
Gene: PRDX2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23576398
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 198
+	Hs
		369052 ESR1_HUMAN (1-595): 0: 599: 100.00		PRDX3_HUMAN (2-198): 8.33e-101: 293: 63.45
+	Hs
		369520 ESR1_HUMAN (1-595): 0: 599: 100.00		PRDX4_HUMAN (5-198): 2.62e-96: 282: 70.10
+	Hs
		369049 ESR1_HUMAN (1-595): 0: 599: 100.00		PRDX6_HUMAN (4-196): 1.88e-67: 207: 29.13
+	Hs
		685741 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRDX2_HUMAN (1-198): 3.46e-104: 299: 100.00
+	Hs
		670988 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRDX3_HUMAN (2-198): 8.33e-101: 293: 63.45
+	Hs
		1026738 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRDX4_HUMAN (5-198): 2.62e-96: 282: 70.10
+	Hs
		377120 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		PRDX3_HUMAN (2-198): 8.33e-101: 293: 63.45
+	Rn
		415149 GCR_RAT (5-557): 9.7e-106: 338: 22.68		PRDX1_RAT (1-197): 3.67e-100: 289: 77.78
+	Hs
		670745 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRDX6_HUMAN (4-196): 1.88e-67: 207: 29.13
+	Hs
		611429 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PRDX4_HUMAN (5-198): 2.62e-96: 282: 70.10
+	Hs
		670707 HNF4G_HUMAN (174-594): 3.43e-112: 343: 23.28		PRDX6_HUMAN (4-196): 1.88e-67: 207: 29.13
+	Hs
		611378 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PRDX6_HUMAN (4-196): 1.88e-67: 207: 29.13
+	Hs
		487909 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		PRDX6_HUMAN (4-196): 1.88e-67: 207: 29.13
+	Hs
		414494 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		PRDX1_HUMAN (1-197): 7.49e-100: 288: 77.78
+	Hs
		487366 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PRDX1_HUMAN (1-197): 7.49e-100: 288: 77.78
+	Hs
		487392 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PRDX4_HUMAN (5-198): 2.62e-96: 282: 70.10