HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: ARP2 (P61160)
Actin-related protein 2 (Actin-like protein 2)
Gene: ACTR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	33731348, 20308691, 21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 394
+	Hs
		896945 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ARP2_HUMAN (1-394): 0: 815: 100.00
+	Hs
		369279 ESR1_HUMAN (1-595): 0: 599: 100.00		ACTB_HUMAN (1-388): 0: 574: 46.65
+	Hs
		369366 ESR1_HUMAN (1-595): 0: 599: 100.00		ACTC_HUMAN (2-388): 0: 569: 46.51
+	Hs
		891937 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ACTB_HUMAN (1-388): 0: 574: 46.65
+	Hs
		929953 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ACTG_HUMAN (3-388): 0: 573: 46.37
+	Hs
		932298 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ACTC_HUMAN (2-388): 0: 569: 46.51
+	Hs
		487284 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ARP2_HUMAN (1-394): 0: 815: 100.00
+	Mm
		521437 NR4A1_MOUSE (83-544): 2.7e-111: 347: 27.16		ACTB_MOUSE (1-388): 0: 574: 46.65
+	Hs
		377235 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ACTG_HUMAN (3-388): 0: 573: 46.37
+	Mm
		509295 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		ACTB_MOUSE (1-388): 0: 574: 46.65
+	Hs
		414480 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		ACTG_HUMAN (3-388): 0: 573: 46.37
+	Hs
		487279 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ACTB_HUMAN (1-388): 0: 574: 46.65