Protein: ILEU
Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1)

Gene: ILEU, SERPINB1
Organism: Homo sapiens
Interactions: 72
UniProt ID: P30740

Gene Ontology (top 5):
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005769 - early endosome
GO:0010951 - negative regulation of endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

664032

PRTN3
Myeloblastin

2

20

Small-scale

0.799

High

721524

FSD1
Fibronectin type III and SPRY domain-containing protein 1

3

16

High-throughput

0.770

High

476526

CEL3B
Chymotrypsin-like elastase family member 3B

1

13

High-throughput

0.691

High

469414

ELNE
Neutrophil elastase

1

20

Small-scale

0.647

High

721491

ILEU
Leukocyte elastase inhibitor

1

10

High-throughput

0.618

High

721537

DD19B
ATP-dependent RNA helicase DDX19B

2

9

High-throughput

0.611

High

721494

SOX2
Transcription factor SOX-2

3

10

High-throughput

0.609

High

721508

ZIC1
Zinc finger protein ZIC 1

2

7

High-throughput

0.574

High

721521

CDK15
Cyclin-dependent kinase 15

2

7

High-throughput

0.574

High

721532

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

325291

OR2A4
Olfactory receptor 2A4

1

13

High-throughput

0.536

High

602745

AATC
Aspartate aminotransferase, cytoplasmic

1

8

High-throughput

0.536

High

721499

T2R41
Taste receptor type 2 member 41

1

1

High-throughput

0.536

High

721507

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.536

High

721515

FA24B
Protein FAM24B

1

1

High-throughput

0.536

High

240856

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.533

High

721505

KPCE
Protein kinase C epsilon type

2

3

High-throughput

0.521

High

721502

HTRA3
Serine protease HTRA3

1

0

High-throughput

0.513

High

721523

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.513

High

721500

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

254834

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.489

High

331638

MBD4
Methyl-CpG-binding domain protein 4

1

1

High-throughput

0.489

High

721497

STX17
Syntaxin-17

1

9

High-throughput

0.489

High

721498

DSCR6
Protein ripply3

1

7

High-throughput

0.489

High

721503

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.489

High

721513

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

1

High-throughput

0.489

High

721514

ELOA2
Elongin-A2

1

2

High-throughput

0.489

High

721526

SRRT
Serrate RNA effector molecule homolog

1

5

High-throughput

0.489

High

721529

COE2
Transcription factor COE2

1

5

High-throughput

0.489

High

721533

KLH11
Kelch-like protein 11

1

6

High-throughput

0.489

High

721536

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

389966

ALBU
Albumin

1

2

High-throughput

0.479

High

400360

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

403856

GCR
Glucocorticoid receptor

1

9

High-throughput

0.479

High

536586

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

721496

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

721506

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

238404

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

721493

ACVL1
Activin receptor type-1-like

1

0

Small-scale

0.458

High

721512

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

554165

BMP4
Bone morphogenetic protein 4

1

8

High-throughput

0.445

High

721510

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.445

High

721522

PKP2
Plakophilin-2

1

7

High-throughput

0.445

High

588000

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

606296

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.437

High

694711

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

721492

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

721495

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.437

High

721501

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

721518

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.437

High

721527

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

5

High-throughput

0.437

High

721528

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

721530

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.437

High

721531

FBX6
F-box only protein 6

1

7

High-throughput

0.437

High

721534

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

721538

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

172499

XPO1
Exportin-1

1

2

Small-scale

0.408

High

261101

NSMA
Sphingomyelin phosphodiesterase 2

1

7

High-throughput

0.407

High

295460

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

7

High-throughput

0.407

High

330056

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

721509

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.407

High

721511

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.407

High

721525

RSRP1
Arginine/serine-rich protein 1

1

4

High-throughput

0.407

High

721535

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

9

High-throughput

0.407

High

721504

TF2B
Transcription initiation factor IIB

3

0

High-throughput

0.347

High

659657

NFYA
Nuclear transcription factor Y subunit alpha

2

0

High-throughput

0.328

High

462763

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

721516

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

721517

ATG4A
Cysteine protease ATG4A

1

0

High-throughput

0.279

Low

721519

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.232

Low

721520

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025