Protein: AACT
Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less]

Gene: AACT, SERPINA3
Organism: Homo sapiens
Interactions: 136
UniProt ID: P01011

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

132960

MATN2
Matrilin-2

1

1

High-throughput

0.691

High

369428

CATG
Cathepsin G

1

20

High-throughput

0.691

High

369485

NECT2
Nectin-2

1

2

High-throughput

0.691

High

369427

ELNE
Neutrophil elastase

1

20

Small-scale

0.647

High

369437

KLK2
Kallikrein-2

1

20

Small-scale

0.647

High

369520

KLK13
Kallikrein-13

1

20

Small-scale

0.647

High

369444

MPI
Mannose-6-phosphate isomerase

2

1

High-throughput

0.628

High

369460

ZIC1
Zinc finger protein ZIC 1

2

7

High-throughput

0.628

High

369494

CDK15
Cyclin-dependent kinase 15

2

6

High-throughput

0.628

High

369505

DDX31
ATP-dependent DNA helicase DDX31

2

4

High-throughput

0.628

High

369508

SHCAF
SIN3-HDAC complex-associated factor

2

2

High-throughput

0.628

High

366134

HPT
Haptoglobin

1

20

High-throughput

0.618

High

369229

ANT3
Antithrombin-III

1

8

High-throughput

0.618

High

369285

A1AT
Alpha-1-antitrypsin

1

8

High-throughput

0.618

High

369447

GRAM
Granzyme M

1

20

Small-scale

0.618

High

369521

DD19B
ATP-dependent RNA helicase DDX19B

2

8

High-throughput

0.611

High

369479

GDPD1
Lysophospholipase D GDPD1

3

1

High-throughput

0.609

High

369501

PHAF1
Phagosome assembly factor 1

3

2

High-throughput

0.609

High

369491

SNX27
Sorting nexin-27

2

1

High-throughput

0.574

High

369511

TB22B
TBC1 domain family member 22B

2

6

High-throughput

0.574

High

369490

DNJC1
DnaJ homolog subfamily C member 1

1

0

Small-scale

0.561

High

369433

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.541

High

369438

LMNB1
Lamin-B1

1

1

High-throughput

0.541

High

132547

UPK1A
Uroplakin-1a

1

8

High-throughput

0.536

High

282338

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.536

High

292508

RENR
Renin receptor

1

6

High-throughput

0.536

High

348301

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

351626

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

352659

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

4

High-throughput

0.536

High

355389

NSD2
Histone-lysine N-methyltransferase NSD2

1

2

High-throughput

0.536

High

369431

SKI
Ski oncogene

1

2

High-throughput

0.536

High

369435

AATC
Aspartate aminotransferase, cytoplasmic

1

7

High-throughput

0.536

High

369440

CCNC
Cyclin-C

1

6

High-throughput

0.536

High

369443

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.536

High

369446

PCP4
Calmodulin regulator protein PCP4

1

3

High-throughput

0.536

High

369450

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.536

High

369453

GABPA
GA-binding protein alpha chain

1

6

High-throughput

0.536

High

369456

FSTL1
Follistatin-related protein 1

1

2

High-throughput

0.536

High

369462

ZN674
Zinc finger protein 674

1

2

High-throughput

0.536

High

369471

APTX
Aprataxin

1

3

High-throughput

0.536

High

369473

CIR1
Corepressor interacting with RBPJ 1

1

1

High-throughput

0.536

High

369499

EGFL8
Epidermal growth factor-like protein 8

1

2

High-throughput

0.536

High

369502

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.536

High

369506

COE2
Transcription factor COE2

1

4

High-throughput

0.536

High

369510

MBNL1
Muscleblind-like protein 1

1

5

High-throughput

0.536

High

369517

PHF11
PHD finger protein 11

1

8

High-throughput

0.536

High

369523

SSUH2
Protein SSUH2 homolog

1

7

High-throughput

0.536

High

369525

RN115
E3 ubiquitin-protein ligase RNF115

1

7

High-throughput

0.536

High

369425

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

369432

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

369448

CASP6
Caspase-6

1

6

High-throughput

0.515

High

369522

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.515

High

369480

NFAM1
NFAT activation molecule 1

1

0

High-throughput

0.513

High

369426

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.501

High

358041

ADH1B
All-trans-retinol dehydrogenase [NAD(+)] ADH1B

1

2

High-throughput

0.494

High

194434

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

229197

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

4

High-throughput

0.489

High

231358

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

High-throughput

0.489

High

254711

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.489

High

325249

OR2A4
Olfactory receptor 2A4

1

11

High-throughput

0.489

High

335213

CXB5
Gap junction beta-5 protein

1

1

High-throughput

0.489

High

369449

STX17
Syntaxin-17

1

9

High-throughput

0.489

High

369452

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

8

High-throughput

0.489

High

369463

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

369465

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.489

High

369466

TGO1
Transport and Golgi organization protein 1 homolog

1

9

High-throughput

0.489

High

369467

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

6

High-throughput

0.489

High

369469

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.489

High

369470

SFXN4
Sideroflexin-4

1

1

High-throughput

0.489

High

369472

MOGT3
2-acylglycerol O-acyltransferase 3

1

7

High-throughput

0.489

High

369476

ELOA2
Elongin-A2

1

2

High-throughput

0.489

High

369477

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

369478

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.489

High

369481

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.489

High

369482

TRI41
E3 ubiquitin-protein ligase TRIM41

1

6

High-throughput

0.489

High

369489

SARAF
Store-operated calcium entry-associated regulatory factor

1

9

High-throughput

0.489

High

369492

F227B
Protein FAM227B

1

2

High-throughput

0.489

High

369493

FMNL2
Formin-like protein 2

1

3

High-throughput

0.489

High

369495

TEFM
Transcription elongation factor, mitochondrial

1

4

High-throughput

0.489

High

369498

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

8

High-throughput

0.489

High

369500

SH23A
SH2 domain-containing protein 3A

1

8

High-throughput

0.489

High

369504

ZDHC6
Palmitoyltransferase ZDHHC6

1

1

High-throughput

0.489

High

369509

TSSP
Thymus-specific serine protease

1

5

High-throughput

0.489

High

369512

KLH11
Kelch-like protein 11

1

5

High-throughput

0.489

High

369515

THA10
THAP domain-containing protein 10

1

1

High-throughput

0.489

High

369519

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

369526

LAMC3
Laminin subunit gamma-3

1

2

High-throughput

0.481

High

179109

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

5

Small-scale

0.479

High

277222

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.479

High

361510

CERU
Ceruloplasmin

1

1

High-throughput

0.479

High

369418

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.479

High

369419

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.479

High

369420

A1AG1
Alpha-1-acid glycoprotein 1

1

1

High-throughput

0.479

High

369421

VTDB
Vitamin D-binding protein

1

2

High-throughput

0.479

High

369422

TRFE
Serotransferrin

1

2

High-throughput

0.479

High

369423

HEMO
Hemopexin

1

1

High-throughput

0.479

High

369424

STAT
Statherin

1

1

High-throughput

0.479

High

369429

CLUS
Clusterin

1

2

High-throughput

0.479

High

369441

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.479

High

369442

LCN1
Lipocalin-1

1

1

High-throughput

0.479

High

369451

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.479

High

369457

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.479

High

369459

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

369461

PROL4
Proline-rich protein 4

1

1

High-throughput

0.479

High

369487

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.479

High

369496

RANB9
Ran-binding protein 9

1

5

High-throughput

0.479

High

369503

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

369524

SHLB1
Endophilin-B1

1

2

High-throughput

0.470

High

369436

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.460

High

369434

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.458

High

369474

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

369507

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

273741

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

1

Small-scale

0.457

High

369430

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.445

High

369445

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.445

High

369454

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

369458

RFTN1
Raftlin

1

1

High-throughput

0.445

High

369497

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.445

High

105061

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

249706

DOK2
Docking protein 2

1

1

High-throughput

0.437

High

360695

COX3
Cytochrome c oxidase subunit 3

1

2

Small-scale

0.437

High

369439

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.426

High

369513

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

1

0

High-throughput

0.426

High

261041

NSMA
Sphingomyelin phosphodiesterase 2

1

7

High-throughput

0.407

High

369468

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.407

High

369518

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

9

High-throughput

0.407

High

369484

SGCD
Delta-sarcoglycan

1

0

High-throughput

0.282

High

369455

TWF1
Twinfilin-1

1

0

High-throughput

0.279

Low

369464

T176B
Transmembrane protein 176B

1

0

High-throughput

0.279

Low

369475

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.279

Low

369486

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

0

High-throughput

0.279

Low

369488

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.268

Low

369516

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.268

Low

190648

MRP5
ATP-binding cassette sub-family C member 5

1

0

High-throughput

0.251

Low

369514

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.251

Low

369483

JPH3
Junctophilin-3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025