HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23576398
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 165
+	Hs
		369479 ESR1_HUMAN (1-595): 0: 599: 100.00		PPID_HUMAN (2-165): 3.38e-88: 263: 59.30
+	Hs
		370711 ESR1_HUMAN (1-595): 0: 599: 100.00		PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28
+	Hs
		368991 ESR1_HUMAN (1-595): 0: 599: 100.00		PPIB_HUMAN (2-165): 9.46e-88: 257: 63.64
+	Hs
		369197 ESR1_HUMAN (1-595): 0: 599: 100.00		RBP2_HUMAN (3-164): 1.87e-73: 240: 66.67
+	Hs
		673704 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PPIF_HUMAN (3-164): 6.26e-92: 267: 76.54
+	Hs
		614404 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PPIB_HUMAN (2-165): 9.46e-88: 257: 63.64
+	Hs
		203546 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PPIH_HUMAN (2-164): 1.38e-84: 247: 53.85
+	Hs
		834806 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RBP2_HUMAN (3-164): 1.87e-73: 240: 66.67
+	Hs
		377276 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		PPID_HUMAN (2-165): 3.38e-88: 263: 59.30
+	Hs
		437638 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		PPID_HUMAN (2-165): 3.38e-88: 263: 59.30
+	Hs
		487372 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PPID_HUMAN (2-165): 3.38e-88: 263: 59.30