HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TBA1B (P68363)
Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]
Gene: TUBA1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	31527615, unassigned1953, 25604459
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 451
+	Hs
		370313 ESR1_HUMAN (1-595): 0: 599: 100.00		TBA1C_HUMAN (1-451): 0: 728: 98.00
+	Hs
		369879 ESR1_HUMAN (1-595): 0: 599: 100.00		TBA1A_HUMAN (1-440): 0: 715: 99.55
+	Hs
		368829 ESR1_HUMAN (1-595): 0: 599: 100.00		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Hs
		320224 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		TBA1C_HUMAN (1-451): 0: 728: 98.00
+	Hs
		377644 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TBA1C_HUMAN (1-451): 0: 728: 98.00
+	Hs
		320203 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		TBA1B_HUMAN (1-440): 0: 717: 100.00
+	Hs
		320154 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Rn
		415140 GCR_RAT (5-557): 9.7e-106: 338: 22.68		TBA1A_RAT (1-440): 0: 715: 99.55
+	Hs
		611416 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		TBA1B_HUMAN (1-440): 0: 717: 100.00
+	Hs
		611460 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		TBA1A_HUMAN (1-440): 0: 715: 99.55
+	Hs
		377012 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Hs
		377239 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TBB4B_HUMAN (1-437): 0: 697: 40.96
+	Mm
		399115 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		TBA3_MOUSE (1-440): 0: 713: 97.73
+	Hs
		428059 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Hs
		414482 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		TBA1B_HUMAN (1-440): 0: 717: 100.00
+	Hs
		414415 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Hs
		414483 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		TBB4B_HUMAN (1-437): 0: 697: 40.96