HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	23403292, 21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 344
+	Hs
		369476 ESR1_HUMAN (1-595): 0: 599: 100.00		SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65
+	Hs
		370350 ESR1_HUMAN (1-595): 0: 599: 100.00		RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05
+	Hs
		369528 ESR1_HUMAN (1-595): 0: 599: 100.00		SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25
+	Hs
		370304 ESR1_HUMAN (1-595): 0: 599: 100.00		RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (1-195): 2.15e-31: 126: 15.53
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Hs
		370551 ESR1_HUMAN (1-595): 0: 599: 100.00		RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		369064 ESR1_HUMAN (1-595): 0: 599: 100.00		TIA1_HUMAN (2-116): 2.8e-11: 66.1: 17.50
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (101-191): 1.24e-10: 64.5: 19.79
+	Hs
		369421 ESR1_HUMAN (1-595): 0: 599: 100.00		TIAR_HUMAN (102-272): 2.65e-09: 59.9: 13.19
+	Hs
		369401 ESR1_HUMAN (1-595): 0: 599: 100.00		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84
+	Hs
		1028586 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22
+	Hs
		993786 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47
+	Hs
		1028757 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25
+	Hs
		1269462 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (1-195): 2.15e-31: 126: 15.53
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Hs
		680471 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIA1_HUMAN (2-116): 2.8e-11: 66.1: 17.50
+	Hs
		963552 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIAR_HUMAN (102-272): 2.65e-09: 59.9: 13.19