Protein: ANT3
Antithrombin-III (ATIII) (Serpin C1)

Gene: ANT3, SERPINC1
Organism: Homo sapiens
Interactions: 67
UniProt ID: P01008

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369252

FCGRN
IgG receptor FcRn large subunit p51

2

3

High-throughput

0.811

High

369228

ANT3
Antithrombin-III

2

9

Small-scale

0.777

High

366074

THRB
Prothrombin

2

20

Small-scale

0.768

High

369257

OS9
Protein OS-9

3

3

High-throughput

0.667

High

369275

TBB1
Tubulin beta-1 chain

3

1

High-throughput

0.667

High

369240

GRAA
Granzyme A

1

20

Small-scale

0.665

High

366239

FA9
Coagulation factor IX

1

20

Small-scale

0.647

High

366273

FA10
Coagulation factor X

1

20

Small-scale

0.647

High

369234

KLK1
Kallikrein-1

1

20

Small-scale

0.647

High

369249

BTD
Biotinidase

3

0

High-throughput

0.638

High

369229

AACT
Alpha-1-antichymotrypsin

1

8

High-throughput

0.618

High

369233

IC1
Plasma protease C1 inhibitor

1

12

High-throughput

0.618

High

369261

TBB8
Tubulin beta-8 chain

2

1

High-throughput

0.611

High

369236

ELNE
Neutrophil elastase

1

20

High-throughput

0.575

High

369276

DDX31
ATP-dependent DNA helicase DDX31

2

4

High-throughput

0.574

High

369239

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.536

High

369241

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.536

High

369280

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.536

High

369283

HYOU1
Hypoxia up-regulated protein 1

1

6

High-throughput

0.536

High

369246

MCH
Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid

1

0

High-throughput

0.513

High

369235

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.501

High

221015

HAIR
Lysine-specific demethylase hairless

1

1

High-throughput

0.489

High

369255

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

8

High-throughput

0.489

High

369262

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

6

High-throughput

0.489

High

369269

HBAP1
HSPB1-associated protein 1

1

3

High-throughput

0.489

High

369271

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

2

High-throughput

0.489

High

369256

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.484

High

369231

KNG1
Kininogen-1

1

1

High-throughput

0.479

High

369232

HRG
Histidine-rich glycoprotein

1

1

High-throughput

0.479

High

369230

CO3
Complement C3

1

0

High-throughput

0.458

High

369245

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.458

High

369237

LEG1
Galectin-1

1

4

High-throughput

0.445

High

369238

CLUS
Clusterin

1

2

High-throughput

0.445

High

369244

LEG3
Galectin-3

1

4

High-throughput

0.445

High

369267

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

3

High-throughput

0.445

High

240436

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.437

High

277220

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.437

High

288327

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

1

Small-scale

0.437

High

360693

COX3
Cytochrome c oxidase subunit 3

1

2

Small-scale

0.437

High

369242

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

369243

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.437

High

369248

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

369250

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.437

High

369253

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

369258

CUL2
Cullin-2

1

6

Small-scale

0.437

High

369264

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

7

Small-scale

0.437

High

369273

FACD2
Fanconi anemia group D2 protein

1

10

High-throughput

0.437

High

369274

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

4

High-throughput

0.437

High

369278

RNF12
E3 ubiquitin-protein ligase RLIM

1

9

High-throughput

0.437

High

369279

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

369282

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

4

Small-scale

0.437

High

369265

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.426

High

369270

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.426

High

369277

RN146
E3 ubiquitin-protein ligase RNF146

1

0

High-throughput

0.426

High

346583

TTC4
Tetratricopeptide repeat protein 4

1

6

High-throughput

0.407

High

369266

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.407

High

369268

SPSB4
SPRY domain-containing SOCS box protein 4

1

9

High-throughput

0.407

High

369251

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

3

0

High-throughput

0.347

High

369272

TEX15
Testis-expressed protein 15

3

0

High-throughput

0.347

High

369260

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

369281

ING4
Inhibitor of growth protein 4

1

0

High-throughput

0.279

Low

247590

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

369247

LMOD1
Leiomodin-1

1

0

High-throughput

0.249

Low

369254

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.249

Low

369259

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.249

Low

369263

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025