HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PRP4K (Q13523)
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)
Gene: PRP4K

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1007
+	Hs
		370582 ESR1_HUMAN (1-595): 0: 599: 100.00		CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92
+	Hs
		368820 ESR1_HUMAN (1-595): 0: 599: 100.00		CDK1_HUMAN (684-1005): 4.59e-124: 381: 25.00
+	Hs
		369006 ESR1_HUMAN (1-595): 0: 599: 100.00		CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45
+	Hs
		1037860 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00
+	Hs
		377303 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00
+	Hs
		1269780 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92
+	Hs
		414730 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		CDK1_HUMAN (684-1005): 4.59e-124: 381: 25.00
+	Hs
		369561 ESR1_HUMAN (1-595): 0: 599: 100.00		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Mm
		509486 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		CDK1_MOUSE (684-1005): 4.99e-123: 378: 25.00
+	Mm
		1142712 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		Q99JW7_MOUSE (686-1005): 4.4e-122: 376: 25.15
+	Hs
		566337 NR1H2_HUMAN (103-548): 4.02e-105: 326: 21.26		KPCA_HUMAN (486-978): 6.58e-123: 391: 15.94
+	Hs
		566310 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		KPCA_HUMAN (486-978): 6.58e-123: 391: 15.94
+	Hs
		740501 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		CDK5_HUMAN (684-1005): 2.54e-117: 363: 26.14
+	Hs
		1044008 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Hs
		414440 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45
+	Hs
		408536 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		KPCB_HUMAN (486-990): 2.48e-122: 390: 15.01
+	Hs
		414697 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		CDK1_HUMAN (684-1005): 4.59e-124: 381: 25.00
+	Hs
		622836 COT2_HUMAN (113-554): 1.44e-106: 328: 22.70		HIPK3_HUMAN (665-1006): 5.03e-40: 163: 31.77
+	Hs
		487758 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		HIPK2_HUMAN (665-1003): 1.49e-39: 161: 32.59