HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005516 - calmodulin binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 2472
+	Hs
		1045473 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		369420 ESR1_HUMAN (1-595): 0: 599: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		369619 ESR1_HUMAN (1-595): 0: 599: 100.00		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		369446 ESR1_HUMAN (1-595): 0: 599: 100.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		166657 ESR1_HUMAN (1-595): 0: 599: 100.00		CE290_HUMAN (808-2443): 1.12e-32: 142: 10.61
+	Hs
		369641 ESR1_HUMAN (1-595): 0: 599: 100.00		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		370715 ESR1_HUMAN (1-595): 0: 599: 100.00		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		368893 ESR1_HUMAN (1-595): 0: 599: 100.00		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211456 ESR1_HUMAN (1-595): 0: 599: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		164649 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		1059246 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		974119 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		1068618 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		1269937 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		828606 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CENPF_HUMAN (1723-2444): 8.12e-13: 77: 9.28
+	Hs
		521591 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211633 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		320227 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		SPTN4_HUMAN (961-2371): 1.09e-21: 105: 13.80
+	Hs
		521532 NR1H3_HUMAN (99-548): 6.2e-112: 343: 20.49		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Mm
		580490 ANDR_MOUSE (32-555): 1.51e-102: 332: 22.04		ACTN2_MOUSE (1843-2210): 5.15e-13: 77: 23.23