HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: K2C78 (Q8N1N4)
Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)
Gene: KRT78

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 520
+	Hs
		369912 ESR1_HUMAN (1-595): 0: 599: 100.00		K2C1B_HUMAN (66-435): 6.29e-126: 381: 56.49
+	Hs
		368816 ESR1_HUMAN (1-595): 0: 599: 100.00		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Hs
		368794 ESR1_HUMAN (1-595): 0: 599: 100.00		K2C1_HUMAN (76-442): 7.29e-112: 347: 56.95
+	Hs
		369795 ESR1_HUMAN (1-595): 0: 599: 100.00		K2C79_HUMAN (9-442): 1.75e-88: 283: 53.14
+	Hs
		368958 ESR1_HUMAN (1-595): 0: 599: 100.00		K2C4_HUMAN (6-443): 3.19e-73: 243: 55.10
+	Hs
		370133 ESR1_HUMAN (1-595): 0: 599: 100.00		KRT35_HUMAN (3-424): 1.7e-69: 231: 24.17
+	Hs
		213976 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KRT86_HUMAN (1-499): 1.62e-103: 321: 39.88
+	Hs
		318855 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		K2C75_HUMAN (2-516): 7.92e-95: 300: 48.22
+	Hs
		943688 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KRT85_HUMAN (3-489): 6.87e-95: 299: 40.77
+	Hs
		611385 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		K22E_HUMAN (83-427): 1.05e-121: 372: 55.65
+	Hs
		1062061 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		K2C72_HUMAN (1-502): 4.44e-85: 274: 47.85
+	Hs
		1231024 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		K2C78_HUMAN (1-520): 1.25e-79: 259: 100.00
+	Hs
		580147 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		K2C4_HUMAN (6-443): 3.19e-73: 243: 55.10
+	Hs
		280820 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KRT36_HUMAN (14-424): 2e-68: 228: 23.84
+	Hs
		408982 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Hs
		487082 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		K2C3_HUMAN (83-428): 5.14e-68: 232: 62.07