Protein: A2ML1
Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9)

Gene: A2ML1
Organism: Homo sapiens
Interactions: 125
UniProt ID: A8K2U0

Gene Ontology (top 5):
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0030414 - peptidase inhibitor activity
GO:0052548 - regulation of endopeptidase activity
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

69465

ANF
Natriuretic peptides A

2

1

High-throughput

0.552

High

69466

FRIH
Ferritin heavy chain

2

1

High-throughput

0.552

High

69562

SCN3B
Sodium channel regulatory subunit beta-3

1

3

High-throughput

0.514

High

69513

ZFAN4
AN1-type zinc finger protein 4

2

1

High-throughput

0.504

High

69521

FRMD1
FERM domain-containing protein 1

2

1

High-throughput

0.504

High

69532

GMCL1
Germ cell-less protein-like 1

2

1

High-throughput

0.504

High

69534

CDK15
Cyclin-dependent kinase 15

2

2

High-throughput

0.504

High

69554

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

2

1

High-throughput

0.504

High

69555

UD110
UDP-glucuronosyltransferase 1A10

2

1

High-throughput

0.504

High

69559

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.504

High

69561

GPT2L
G patch domain-containing protein 2-like

2

1

High-throughput

0.504

High

69451

UPK1A
Uroplakin-1a

1

1

High-throughput

0.445

High

69459

RASF9
Ras association domain-containing protein 9

1

1

High-throughput

0.445

High

69467

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

High-throughput

0.445

High

69470

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.445

High

69473

BMP4
Bone morphogenetic protein 4

1

6

High-throughput

0.445

High

69474

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.445

High

69477

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

5

High-throughput

0.445

High

69481

PI4KA
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.445

High

69491

FSTL1
Follistatin-related protein 1

1

2

High-throughput

0.445

High

69495

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.445

High

69549

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

2

High-throughput

0.445

High

69571

GSTK1
Glutathione S-transferase kappa 1

1

1

High-throughput

0.445

High

69525

GP148
Probable G-protein coupled receptor 148

1

1

High-throughput

0.437

High

69493

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.426

High

51523

PL8L1
PLAC8-like protein 1

1

1

High-throughput

0.407

High

64783

EPAB2
Embryonic polyadenylate-binding protein 2

1

1

High-throughput

0.407

High

69452

RTCA
RNA 3'-terminal phosphate cyclase

1

1

High-throughput

0.407

High

69453

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.407

High

69454

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

High-throughput

0.407

High

69456

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

69457

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.407

High

69458

FOXH1
Forkhead box protein H1

1

9

High-throughput

0.407

High

69460

TOX4
TOX high mobility group box family member 4

1

7

High-throughput

0.407

High

69461

OR2A4
Olfactory receptor 2A4

1

3

High-throughput

0.407

High

69462

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.407

High

69463

MBD4
Methyl-CpG-binding domain protein 4

1

3

High-throughput

0.407

High

69464

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.407

High

69469

THA
Thyroid hormone receptor alpha

1

1

High-throughput

0.407

High

69471

PIM1
Serine/threonine-protein kinase pim-1

1

1

High-throughput

0.407

High

69472

ADT3
ADP/ATP translocase 3

1

4

High-throughput

0.407

High

69475

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

2

High-throughput

0.407

High

69476

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

High-throughput

0.407

High

69478

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.407

High

69479

GRK4
G protein-coupled receptor kinase 4

1

1

High-throughput

0.407

High

69482

PCP4
Calmodulin regulator protein PCP4

1

1

High-throughput

0.407

High

69483

ASCL1
Achaete-scute homolog 1

1

2

High-throughput

0.407

High

69485

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.407

High

69486

STX17
Syntaxin-17

1

4

High-throughput

0.407

High

69487

DSCR6
Protein ripply3

1

2

High-throughput

0.407

High

69488

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.407

High

69489

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.407

High

69490

GABPA
GA-binding protein alpha chain

1

1

High-throughput

0.407

High

69492

FOXD4
Forkhead box protein D4

1

4

High-throughput

0.407

High

69494

ZN154
Zinc finger protein 154

1

1

High-throughput

0.407

High

69496

BAK
Bcl-2 homologous antagonist/killer

1

1

High-throughput

0.407

High

69497

UPP1
Uridine phosphorylase 1

1

1

High-throughput

0.407

High

69498

INSC
Protein inscuteable homolog

1

1

High-throughput

0.407

High

69499

CR021
UPF0711 protein C18orf21

1

3

High-throughput

0.407

High

69500

LRC10
Leucine-rich repeat-containing protein 10

1

1

High-throughput

0.407

High

69501

BEX5
Protein BEX5

1

1

High-throughput

0.407

High

69502

MYOME
Myomegalin

1

4

High-throughput

0.407

High

69503

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.407

High

69505

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.407

High

69506

APTX
Aprataxin

1

1

High-throughput

0.407

High

69507

ZN550
Zinc finger protein 550

1

1

High-throughput

0.407

High

69509

MOGT3
2-acylglycerol O-acyltransferase 3

1

1

High-throughput

0.407

High

69511

COA5
Cytochrome c oxidase assembly factor 5

1

1

High-throughput

0.407

High

69512

AROS
Active regulator of SIRT1

1

1

High-throughput

0.407

High

69514

CERS3
Ceramide synthase 3

1

2

High-throughput

0.407

High

69515

YAF2
YY1-associated factor 2

1

5

High-throughput

0.407

High

69516

UBAD2
UBA-like domain-containing protein 2

1

1

High-throughput

0.407

High

69517

NRSN1
Neurensin-1

1

3

High-throughput

0.407

High

69518

S39AB
Zinc transporter ZIP11

1

1

High-throughput

0.407

High

69519

FGRL1
Fibroblast growth factor receptor-like 1

1

2

High-throughput

0.407

High

69520

CCYL1
Cyclin-Y-like protein 1

1

1

High-throughput

0.407

High

69522

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

69523

FNDC5
Fibronectin type III domain-containing protein 5

1

3

High-throughput

0.407

High

69524

NFAM1
NFAT activation molecule 1

1

1

High-throughput

0.407

High

69526

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.407

High

69527

PIGT
GPI-anchor transamidase component PIGT

1

3

High-throughput

0.407

High

69528

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.407

High

69529

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.407

High

69530

ASB9
Ankyrin repeat and SOCS box protein 9

1

1

High-throughput

0.407

High

69533

FMNL2
Formin-like protein 2

1

1

High-throughput

0.407

High

69535

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.407

High

69536

FCRL5
Fc receptor-like protein 5

1

4

High-throughput

0.407

High

69537

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.407

High

69538

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

5

High-throughput

0.407

High

69539

PKP2
Plakophilin-2

1

5

High-throughput

0.407

High

69540

TREX2
Three prime repair exonuclease 2

1

1

High-throughput

0.407

High

69541

SH23A
SH2 domain-containing protein 3A

1

3

High-throughput

0.407

High

69542

PXL2A
Peroxiredoxin-like 2A

1

1

High-throughput

0.407

High

69543

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.407

High

69545

5NT1A
Cytosolic 5'-nucleotidase 1A

1

1

High-throughput

0.407

High

69546

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.407

High

69547

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.407

High

69548

PDIP3
Polymerase delta-interacting protein 3

1

1

High-throughput

0.407

High

69550

FBX44
F-box only protein 44

1

4

High-throughput

0.407

High

69551

DUS21
Dual specificity protein phosphatase 21

1

2

High-throughput

0.407

High

69552

ZDHC6
Palmitoyltransferase ZDHHC6

1

2

High-throughput

0.407

High

69553

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.407

High

69556

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.407

High

69557

MBNL1
Muscleblind-like protein 1

1

3

High-throughput

0.407

High

69558

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.407

High

69560

KLH11
Kelch-like protein 11

1

1

High-throughput

0.407

High

69563

TLR7
Toll-like receptor 7

1

1

High-throughput

0.407

High

69564

VSX1
Visual system homeobox 1

1

5

High-throughput

0.407

High

69565

GSKIP
GSK3B-interacting protein

1

1

High-throughput

0.407

High

69566

THA10
THAP domain-containing protein 10

1

1

High-throughput

0.407

High

69567

PHF11
PHD finger protein 11

1

5

High-throughput

0.407

High

69568

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

4

High-throughput

0.407

High

69569

COR1C
Coronin-1C

1

2

High-throughput

0.407

High

69570

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.407

High

69572

RN115
E3 ubiquitin-protein ligase RNF115

1

2

High-throughput

0.407

High

69455

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

0

High-throughput

0.288

High

69468

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low

69480

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.232

Low

69484

T2AG
Transcription initiation factor IIA subunit 2

1

0

High-throughput

0.232

Low

69504

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.232

Low

69508

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.232

Low

69510

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.232

Low

69531

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.232

Low

69544

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low

69573

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025