HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TAB3 (Q8N5C8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
Gene: TAB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26389696
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 712
+	Hs
		370578 ESR1_HUMAN (1-595): 0: 599: 100.00		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Hs
		369214 ESR1_HUMAN (1-595): 0: 599: 100.00		SMCA4_HUMAN (153-599): 1.86e-39: 159: 11.43
+	Hs
		369213 ESR1_HUMAN (1-595): 0: 599: 100.00		SMCA2_HUMAN (176-599): 1.02e-36: 150: 13.59
+	Hs
		368927 ESR1_HUMAN (1-595): 0: 599: 100.00		MUC1_HUMAN (54-680): 4.91e-23: 107: 9.24
+	Hs
		370607 ESR1_HUMAN (1-595): 0: 599: 100.00		CHD7_HUMAN (1-369): 4.12e-17: 88.3: 14.25
+	Hs
		370105 ESR1_HUMAN (1-595): 0: 599: 100.00		TITIN_HUMAN (134-417): 2.57e-09: 63.2: 9.72
+	Hs
		1269776 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Hs
		847036 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMCA4_HUMAN (153-599): 1.86e-39: 159: 11.43
+	Hs
		846832 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMCA2_HUMAN (176-599): 1.02e-36: 150: 13.59
+	Hs
		587141 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		SMCA4_HUMAN (153-599): 1.86e-39: 159: 11.43
+	Hs
		1186078 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MICA3_HUMAN (61-685): 7.87e-31: 132: 9.58
+	Hs
		782504 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		SMCA4_HUMAN (153-599): 1.86e-39: 159: 11.43
+	Hs
		554348 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MUC1_HUMAN (54-680): 4.91e-23: 107: 9.24
+	Hs
		782503 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		SMCA2_HUMAN (176-599): 1.02e-36: 150: 13.59
+	Hs
		1269367 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CHAP1_HUMAN (63-511): 1.2e-19: 96: 13.16
+	Hs
		1269810 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CHD7_HUMAN (1-369): 4.12e-17: 88.3: 14.25
+	Hs
		867111 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SC24C_HUMAN (210-493): 5.8e-12: 71.3: 13.44
+	Hs
		1270066 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PCLO_HUMAN (60-674): 1.23e-10: 67.5: 10.59
+	Hs
		302306 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SC31A_HUMAN (220-598): 4.01e-10: 65.5: 13.19
+	Hs
		1264774 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TITIN_HUMAN (134-417): 2.57e-09: 63.2: 9.72