Protein: TIMP1
Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)

Gene: TIMP1
Organism: Homo sapiens
Interactions: 45
UniProt ID: P01033

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0002248 - connective tissue replacement involved in inflammatory response wound healing
GO:0005125 - cytokine activity
GO:0005576 - extracellular region
GO:0005604 - basement membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369998

MMP9
Matrix metalloproteinase-9

4

20

Small-scale

0.892

High

370008

MMP14
Matrix metalloproteinase-14

3

20

Small-scale

0.834

High

369989

MMP1
Interstitial collagenase

2

20

Small-scale

0.830

High

369996

MMP10
Stromelysin-2

2

20

High-throughput

0.811

High

369992

MMP2
72 kDa type IV collagenase

2

20

Small-scale

0.789

High

369993

MMP3
Stromelysin-1

2

20

Small-scale

0.789

High

369995

CD63
CD63 antigen

4

1

Small-scale

0.700

High

369994

IBP1
Insulin-like growth factor-binding protein 1

2

2

High-throughput

0.628

High

370004

FGFR2
Fibroblast growth factor receptor 2

2

3

High-throughput

0.628

High

370020

FBX6
F-box only protein 6

3

1

High-throughput

0.599

High

370006

CD82
CD82 antigen

1

1

Small-scale

0.557

High

370011

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

1

High-throughput

0.541

High

342480

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

369990

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.536

High

370015

KRT35
Keratin, type I cuticular Ha5

1

9

High-throughput

0.536

High

370016

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.536

High

370018

CST11
Cystatin-11

1

2

High-throughput

0.536

High

370023

KLK5
Kallikrein-5

1

2

High-throughput

0.536

High

370010

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

Small-scale

0.529

High

370001

TSHR
Thyrotropin receptor

1

0

High-throughput

0.513

High

370007

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.513

High

370019

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

370003

CO5A1

1

7

Small-scale

0.506

High

369987

TIMP1
Metalloproteinase inhibitor 1

1

3

Small-scale

0.501

High

370013

NTRK3
NT-3 growth factor receptor

1

3

High-throughput

0.500

High

316241

RECQ5
ATP-dependent DNA helicase Q5

1

2

High-throughput

0.494

High

229198

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

1

High-throughput

0.489

High

369991

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

5

High-throughput

0.489

High

370022

FBX2
F-box only protein 2

1

1

High-throughput

0.489

High

369997

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

362540

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

369988

CYTN
Cystatin-SN

1

2

Small-scale

0.479

High

370000

TIMP2
Metalloproteinase inhibitor 2

1

3

High-throughput

0.479

High

370017

MYOC
Myocilin

1

0

Small-scale

0.460

High

217682

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

369999

GATA1
Erythroid transcription factor

1

0

Small-scale

0.458

High

370012

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

370021

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

Small-scale

0.458

High

370005

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.282

High

168359

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.279

Low

219790

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.279

Low

370014

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.279

Low

370002

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

370009

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025