Protein: TIMP3
Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)

Gene: TIMP3
Organism: Homo sapiens
Interactions: 111
UniProt ID: P35625

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005604 - basement membrane
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0007601 - visual perception

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

774756

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

4

6

Small-scale

0.886

High

469666

MMP2
72 kDa type IV collagenase

3

20

Small-scale

0.866

High

469709

MMP3
Stromelysin-1

2

20

High-throughput

0.789

High

774751

MMP14
Matrix metalloproteinase-14

2

20

High-throughput

0.776

High

590825

TIMP2
Metalloproteinase inhibitor 2

3

3

High-throughput

0.667

High

561111

GILT
Gamma-interferon-inducible lysosomal thiol reductase

3

0

High-throughput

0.638

High

388502

CRP

3

0

High-throughput

0.634

High

421609

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.628

High

774787

NELL1
Protein kinase C-binding protein NELL1

2

9

High-throughput

0.628

High

774798

COL11
Collectin-11

2

6

High-throughput

0.611

High

774818

COL10
Collectin-10

2

8

High-throughput

0.611

High

774747

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

2

0

High-throughput

0.602

High

774796

ADPGK
ADP-dependent glucokinase

2

0

High-throughput

0.602

High

774746

PPM1A
Protein phosphatase 1A

2

1

High-throughput

0.601

High

774761

NOTC2
Neurogenic locus notch homolog protein 2

2

2

High-throughput

0.601

High

774791

VWCE
von Willebrand factor C and EGF domain-containing protein

2

10

High-throughput

0.601

High

774810

DKK3
Dickkopf-related protein 3

2

0

High-throughput

0.576

High

62098

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

1

High-throughput

0.574

High

207800

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

2

1

High-throughput

0.549

High

437633

HEPS
Serine protease hepsin

2

2

High-throughput

0.549

High

774773

HECD3
E3 ubiquitin-protein ligase HECTD3

2

1

High-throughput

0.549

High

774789

COA7
Cytochrome c oxidase assembly factor 7

2

1

High-throughput

0.549

High

245677

GANP
Germinal-center associated nuclear protein

1

2

High-throughput

0.536

High

290876

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.536

High

476429

IBP1
Insulin-like growth factor-binding protein 1

1

2

High-throughput

0.536

High

476527

CEL3B
Chymotrypsin-like elastase family member 3B

1

3

High-throughput

0.536

High

518815

CCL3
C-C motif chemokine 3

1

2

High-throughput

0.536

High

551765

CO6A1

1

4

High-throughput

0.536

High

593294

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.536

High

598253

CL3L1
C-C motif chemokine 3-like 1

1

2

High-throughput

0.536

High

650528

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

1

High-throughput

0.536

High

651620

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

1

High-throughput

0.536

High

774752

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.536

High

774754

DEF1
Neutrophil defensin 1

1

1

High-throughput

0.536

High

774760

DEF5
Defensin alpha 5

1

1

High-throughput

0.536

High

774772

FREM2
FRAS1-related extracellular matrix protein 2

1

2

High-throughput

0.536

High

774779

FRAS1
Extracellular matrix organizing protein FRAS1

1

6

High-throughput

0.536

High

774786

SORL
Sortilin-related receptor

1

4

High-throughput

0.536

High

774795

WFDC6
WAP four-disulfide core domain protein 6

1

2

High-throughput

0.536

High

774799

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

5

High-throughput

0.536

High

774814

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

4

High-throughput

0.536

High

774817

ST14
Suppressor of tumorigenicity 14 protein

1

5

High-throughput

0.536

High

193089

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

0

High-throughput

0.513

High

316656

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.513

High

416598

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.513

High

452186

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.513

High

465836

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.513

High

774762

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.513

High

774764

SG2A2
Mammaglobin-A

1

0

High-throughput

0.513

High

774792

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.513

High

774794

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.513

High

774797

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.513

High

774804

CAD23
Cadherin-23

1

0

High-throughput

0.513

High

273751

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

5

Small-scale

0.501

High

774815

ATS5
A disintegrin and metalloproteinase with thrombospondin motifs 5

1

5

Small-scale

0.501

High

274861

LRP5
Low-density lipoprotein receptor-related protein 5

1

4

High-throughput

0.489

High

376484

LDLR
Low-density lipoprotein receptor

1

4

High-throughput

0.489

High

774757

IDD
Integral membrane protein DGCR2/IDD

1

6

High-throughput

0.489

High

774758

LRP2
Low-density lipoprotein receptor-related protein 2

1

4

High-throughput

0.489

High

774775

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

6

High-throughput

0.489

High

774801

TMPSD
Transmembrane protease serine 13

1

6

High-throughput

0.489

High

774803

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.489

High

774805

TOR3A
Torsin-3A

1

1

High-throughput

0.489

High

774809

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

5

High-throughput

0.489

High

774811

SE1L1
Protein sel-1 homolog 1

1

10

High-throughput

0.489

High

371330

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

405847

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

774766

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

6

Small-scale

0.479

High

774768

ELAV1
ELAV-like protein 1

1

1

Small-scale

0.479

High

474518

VIME
Vimentin

1

6

High-throughput

0.470

High

774812

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

774769

NTRK3
NT-3 growth factor receptor

1

3

High-throughput

0.457

High

73780

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

6

High-throughput

0.445

High

342519

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.445

High

429411

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

479046

CEL3A
Chymotrypsin-like elastase family member 3A

1

3

High-throughput

0.445

High

505803

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

5

High-throughput

0.445

High

774763

LG3BP
Galectin-3-binding protein

1

1

High-throughput

0.445

High

774765

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

5

High-throughput

0.445

High

774767

LAMB3
Laminin subunit beta-3

1

3

High-throughput

0.445

High

774806

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

679308

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.426

High

774748

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.426

High

774755

LCN6
Epididymal-specific lipocalin-6

1

0

High-throughput

0.426

High

774776

GASP3
G protein-coupled receptor associated sorting protein 3

1

0

High-throughput

0.426

High

774780

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.426

High

774781

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.426

High

774785

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.426

High

455954

ASGR2
Asialoglycoprotein receptor 2

3

0

High-throughput

0.347

High

774750

AGTR2
Type-2 angiotensin II receptor

1

0

Small-scale

0.305

High

725358

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.279

Low

774749

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.279

Low

774759

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.279

Low

774771

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

0

High-throughput

0.279

Low

774774

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.279

Low

774782

STK40
Serine/threonine-protein kinase 40

1

0

High-throughput

0.279

Low

774783

PGLT1
Protein O-glucosyltransferase 1

1

0

High-throughput

0.279

Low

774790

F136A
Protein FAM136A

1

0

High-throughput

0.279

Low

774800

TMM59
Transmembrane protein 59

1

0

High-throughput

0.279

Low

774813

AKA11
A-kinase anchor protein 11

1

0

High-throughput

0.279

Low

774753

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

774770

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

774788

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.249

Low

774808

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

774777

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.232

Low

774778

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.232

Low

774784

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.232

Low

774793

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

774802

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low

774807

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low

774816

PCDBB
Protocadherin beta-11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025