HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PBIP1 (Q96AQ6)
Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein)
Gene: PBXIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	17043237, 31527615, unassigned1953
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005829 - cytosol and 1 others more... GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 731
+	Hs
		1269315 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PBIP1_HUMAN (1-731): 0: 569: 100.00
+	Hs
		369789 ESR1_HUMAN (1-595): 0: 599: 100.00		MRCKA_HUMAN (13-470): 6.92e-69: 248: 12.73
+	Hs
		370819 ESR1_HUMAN (1-595): 0: 599: 100.00		MRCKB_HUMAN (33-530): 5.38e-57: 212: 10.31
+	Hs
		370120 ESR1_HUMAN (1-595): 0: 599: 100.00		MY18A_HUMAN (14-559): 2.17e-52: 199: 15.54
+	Hs
		368902 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH6_HUMAN (9-532): 6.29e-29: 126: 10.73
+	Hs
		148263 ESR1_HUMAN (1-595): 0: 599: 100.00		CTRO_HUMAN (20-557): 7.59e-14: 77.8: 9.96
+	Hs
		1270038 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MRCKB_HUMAN (33-530): 5.38e-57: 212: 10.31
+	Hs
		64608 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH7B_HUMAN (31-553): 3.57e-53: 201: 12.89
+	Hs
		1268061 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MY18A_HUMAN (14-559): 2.17e-52: 199: 15.54
+	Hs
		659748 RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64		MRCKB_HUMAN (33-530): 5.38e-57: 212: 10.31
+	Hs
		522631 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH7_HUMAN (9-532): 1.62e-30: 131: 11.27
+	Hs
		1269900 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH13_HUMAN (21-532): 1.34e-29: 128: 11.49
+	Hs
		1270044 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH4_HUMAN (9-532): 2.44e-28: 124: 10.00
+	Hs
		149132 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CTRO_HUMAN (20-557): 7.59e-14: 77.8: 9.96
+	Hs
		377795 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		MYH2_HUMAN (21-532): 1.98e-28: 124: 10.73
+	Hs
		487504 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		MRCKA_HUMAN (13-470): 6.92e-69: 248: 12.73
+	Hs
		487627 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		MY18A_HUMAN (14-559): 2.17e-52: 199: 15.54