Protein: CYTM
Cystatin-M (Cystatin-6) (Cystatin-E)

Gene: CYTM, CST6
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q15828

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0008544 - epidermis development
GO:0009653 - anatomical structure morphogenesis
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1154341

LGMN
Legumain

3

3

Small-scale

0.879

High

459297

CATL1
Procathepsin L

2

13

High-throughput

0.776

High

922219

CATC
Dipeptidyl peptidase 1

2

17

High-throughput

0.776

High

261623

CATL2
Cathepsin L2

2

13

High-throughput

0.694

High

292293

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

2

4

High-throughput

0.558

High

1154355

CLC5A
C-type lectin domain family 5 member A

2

2

High-throughput

0.558

High

1154356

EHF
ETS homologous factor

2

1

High-throughput

0.558

High

132595

UPK1A
Uroplakin-1a

1

1

High-throughput

0.536

High

388821

CO9
Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

1

2

High-throughput

0.536

High

391618

FRIH
Ferritin heavy chain

1

3

High-throughput

0.536

High

788309

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

1

High-throughput

0.536

High

845033

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.536

High

940354

ITA1
Integrin alpha-1

1

3

High-throughput

0.536

High

1087051

FSTL1
Follistatin-related protein 1

1

1

High-throughput

0.536

High

899694

ANX11
Annexin A11

1

1

High-throughput

0.515

High

292636

RENR
Renin receptor

1

0

High-throughput

0.513

High

705352

GRN
Progranulin

1

0

High-throughput

0.513

High

984124

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

1154331

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.513

High

294865

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

2

High-throughput

0.494

High

376841

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.494

High

1047556

NOTC2
Neurogenic locus notch homolog protein 2

1

5

High-throughput

0.494

High

173928

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.489

High

282725

E2F6
Transcription factor E2F6

1

2

High-throughput

0.489

High

318483

TOX4
TOX high mobility group box family member 4

1

1

High-throughput

0.489

High

338691

VNN2
Pantetheine hydrolase VNN2

1

1

High-throughput

0.489

High

533291

THA
Thyroid hormone receptor alpha

1

1

High-throughput

0.489

High

1055607

GABPA
GA-binding protein alpha chain

1

1

High-throughput

0.489

High

1112506

CUL1
Cullin-1

1

2

High-throughput

0.489

High

1127910

PDIA5
Protein disulfide-isomerase A5

1

3

High-throughput

0.489

High

1154316

SE6L2
Seizure 6-like protein 2

1

1

High-throughput

0.489

High

1154320

CLC10
C-type lectin domain family 10 member A

1

2

High-throughput

0.489

High

1154337

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

2

High-throughput

0.489

High

1154342

SH23A
SH2 domain-containing protein 3A

1

1

High-throughput

0.489

High

1154345

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.489

High

1154349

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

3

High-throughput

0.489

High

891575

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.464

High

293747

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

315630

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.437

High

1154339

RANB9
Ran-binding protein 9

1

4

Small-scale

0.437

High

1154362

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.437

High

449569

HEXA
Beta-hexosaminidase subunit alpha

1

0

High-throughput

0.426

High

981836

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.426

High

1154315

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1154335

PCD16
Protocadherin-16

1

3

High-throughput

0.407

High

1154357

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

6

High-throughput

0.407

High

1154321

DAA19
Dynein axonemal assembly factor 19

2

0

High-throughput

0.328

High

1154350

SHCAF
SIN3-HDAC complex-associated factor

2

0

High-throughput

0.328

High

74210

CF97D
Sperm axonemal maintenance protein CFAP97D1

2

0

High-throughput

0.318

High

764230

CAH8
Carbonic anhydrase-related protein

2

0

High-throughput

0.318

High

1098191

MMRN1
Multimerin-1

2

0

High-throughput

0.318

High

1154319

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

2

0

High-throughput

0.318

High

1154343

PHAF1
Phagosome assembly factor 1

2

0

High-throughput

0.318

High

1154346

NUSAP
Nucleolar and spindle-associated protein 1

2

0

High-throughput

0.318

High

325550

YIF1A
Protein YIF1A

2

0

High-throughput

0.316

High

332305

ATE1
Arginyl-tRNA--protein transferase 1

2

0

High-throughput

0.313

High

1154333

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.313

High

213408

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

0

High-throughput

0.288

High

1055917

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.282

High

1154318

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.282

High

370683

FOS
Protein c-Fos

1

0

High-throughput

0.279

Low

376988

ANF
Natriuretic peptides A

1

0

High-throughput

0.279

Low

420253

IFNA4
Interferon alpha-4

1

0

High-throughput

0.279

Low

584547

VAV
Proto-oncogene vav

1

0

High-throughput

0.279

Low

722787

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.279

Low

876332

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

1144351

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.279

Low

1149073

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.279

Low

1154314

MYOME
Myomegalin

1

0

High-throughput

0.279

Low

1154317

ZN550
Zinc finger protein 550

1

0

High-throughput

0.279

Low

1154322

YAF2
YY1-associated factor 2

1

0

High-throughput

0.279

Low

1154323

ZDH23
Palmitoyltransferase ZDHHC23

1

0

High-throughput

0.279

Low

1154324

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1154325

D106A
Beta-defensin 106

1

0

High-throughput

0.279

Low

1154326

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.279

Low

1154327

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1154328

TRI41
E3 ubiquitin-protein ligase TRIM41

1

0

High-throughput

0.279

Low

1154329

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.279

Low

1154330

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

0

High-throughput

0.279

Low

1154338

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

1154347

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.279

Low

1154351

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

1154352

XPP3
Xaa-Pro aminopeptidase 3

1

0

High-throughput

0.279

Low

1154353

TB22B
TBC1 domain family member 22B

1

0

High-throughput

0.279

Low

1154354

KLH11
Kelch-like protein 11

1

0

High-throughput

0.279

Low

1154358

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.279

Low

1154361

FCF1
rRNA-processing protein FCF1 homolog

1

0

High-throughput

0.279

Low

276133

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

413913

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

418151

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

711642

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.249

Low

1154332

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1154336

CF418
Cilia- and flagella-associated protein 418

1

0

High-throughput

0.249

Low

1154348

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.249

Low

1154360

NINL
Ninein-like protein

1

0

High-throughput

0.249

Low

839556

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.232

Low

1154313

CERKL
Ceramide kinase-like protein

1

0

High-throughput

0.232

Low

1154334

ASB9
Ankyrin repeat and SOCS box protein 9

1

0

High-throughput

0.232

Low

1154340

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low

1154344

SYT11
Synaptotagmin-11

1

0

High-throughput

0.232

Low

1154359

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025