HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	31527615, 21182205, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 3159
+	Hs
		782636 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		229273 ESR1_HUMAN (1-595): 0: 599: 100.00		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		369729 ESR1_HUMAN (1-595): 0: 599: 100.00		CHD9_HUMAN (1565-2538): 3.24e-144: 509: 13.41
+	Hs
		370482 ESR1_HUMAN (1-595): 0: 599: 100.00		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Hs
		229452 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		370686 ESR1_HUMAN (1-595): 0: 599: 100.00		INO80_HUMAN (1754-2150): 2.56e-83: 307: 25.38
+	Hs
		1269673 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Hs
		587181 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		CHD9_HUMAN (1565-2538): 3.24e-144: 509: 13.41
+	Hs
		1269907 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		INO80_HUMAN (1754-2150): 2.56e-83: 307: 25.38
+	Hs
		370607 ESR1_HUMAN (1-595): 0: 599: 100.00		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		369213 ESR1_HUMAN (1-595): 0: 599: 100.00		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		369214 ESR1_HUMAN (1-595): 0: 599: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		1269613 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMRCD_HUMAN (1895-2052): 1.85e-24: 115: 38.27
+	Hs
		1269810 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		846832 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		847036 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		782578 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		587141 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		782503 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		782504 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17