HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: WDR18 (Q9BV38)
WD repeat-containing protein 18
Gene: WDR18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 432
+	Hs
		369305 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5_HUMAN (152-432): 8.2e-55: 186: 14.75
+	Hs
		369932 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5B_HUMAN (208-432): 9.97e-43: 154: 13.66
+	Hs
		370309 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1Y_HUMAN (3-108): 1.04e-26: 114: 14.95
+	Hs
		370377 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1R_HUMAN (5-110): 6.4e-27: 114: 14.02
+	Hs
		1269504 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		WDR18_HUMAN (1-432): 4.37e-93: 288: 100.00
+	Hs
		369669 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF5_HUMAN (9-141): 3.19e-12: 70.5: 15.19
+	Hs
		903403 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		WDR5_HUMAN (152-432): 8.2e-55: 186: 14.75
+	Hs
		377562 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		FBXW7_HUMAN (66-406): 4.11e-66: 225: 18.26
+	Hs
		782513 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		WDR5_HUMAN (152-432): 8.2e-55: 186: 14.75
+	Hs
		560885 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GBB3_HUMAN (115-339): 3.33e-35: 135: 16.52
+	Mm
		903664 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		WDR5_MOUSE (152-432): 8.2e-55: 186: 14.75
+	Hs
		1269746 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NLE1_HUMAN (1-106): 3.14e-28: 117: 19.63
+	Hs
		1269467 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1Y_HUMAN (3-108): 1.04e-26: 114: 14.95
+	Hs
		1269548 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1R_HUMAN (5-110): 6.4e-27: 114: 14.02
+	Hs
		488008 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		SNR40_HUMAN (113-413): 1.61e-57: 194: 14.80
+	Hs
		320167 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		GBB3_HUMAN (115-339): 3.33e-35: 135: 16.52
+	Hs
		1074801 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAF5_HUMAN (9-141): 3.19e-12: 70.5: 15.19
+	Hs
		245574 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TBL1X_HUMAN (3-110): 1.72e-27: 116: 13.76
+	Hs
		488022 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		TBL1R_HUMAN (5-110): 6.4e-27: 114: 14.02
+	Hs
		782550 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TAF5_HUMAN (9-141): 3.19e-12: 70.5: 15.19