Protein: VPS11
Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)

Gene: VPS11
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q9H270

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1431601

VPS18
Vacuolar protein sorting-associated protein 18 homolog

11

20

Small-scale

0.756

High

1394867

VPS39
Vam6/Vps39-like protein

10

16

Small-scale

0.756

High

1356708

TGFA1
Transforming growth factor-beta receptor-associated protein 1

9

16

Small-scale

0.752

High

1383672

VP33A
Vacuolar protein sorting-associated protein 33A

7

17

Small-scale

0.746

High

888816

VPS41
Vacuolar protein sorting-associated protein 41 homolog

7

17

Small-scale

0.745

High

1431575

VPS16
Vacuolar protein sorting-associated protein 16 homolog

6

13

Small-scale

0.736

High

765880

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.695

High

1325279

VPS8
Vacuolar protein sorting-associated protein 8 homolog

4

7

Small-scale

0.694

High

1431606

PKHM1
Pleckstrin homology domain-containing family M member 1

3

3

Small-scale

0.656

High

982321

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

3

High-throughput

0.647

High

996020

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

4

High-throughput

0.647

High

901560

RAB7A
Ras-related protein Rab-7a

3

17

Small-scale

0.646

High

171924

ZN263
Zinc finger protein 263

2

1

High-throughput

0.628

High

1218762

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

5

High-throughput

0.625

High

950682

KR108
Keratin-associated protein 10-8

3

2

High-throughput

0.616

High

1431603

RBX2
RING-box protein 2

2

1

High-throughput

0.601

High

957669

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

4

High-throughput

0.594

High

1382339

RN166
E3 ubiquitin-protein ligase RNF166

1

0

High-throughput

0.586

High

1178959

TM266
Transmembrane protein 266

2

1

High-throughput

0.574

High

1382748

ISOC2
Isochorismatase domain-containing protein 2

2

1

High-throughput

0.574

High

582955

EZRI
Ezrin

1

2

Small-scale

0.573

High

1054645

PSME1
Proteasome activator complex subunit 1

2

1

High-throughput

0.549

High

1093423

TRI32
E3 ubiquitin-protein ligase TRIM32

1

1

High-throughput

0.541

High

1248442

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

1

High-throughput

0.541

High

857557

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.536

High

1307147

TCAM1
TIR domain-containing adapter molecule 1

1

1

High-throughput

0.536

High

1384129

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.536

High

189831

STX7
Syntaxin-7

1

14

Small-scale

0.534

High

1398893

RILP
Rab-interacting lysosomal protein

1

3

Small-scale

0.527

High

1407460

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.518

High

1431599

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.518

High

943130

STX17
Syntaxin-17

1

4

Small-scale

0.515

High

423144

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

683892

MOES
Moesin

1

2

Small-scale

0.501

High

767498

RADI
Radixin

1

2

Small-scale

0.501

High

1159635

STX1A
Syntaxin-1A

1

13

Small-scale

0.501

High

1431598

GGA3
ADP-ribosylation factor-binding protein GGA3

1

3

Small-scale

0.501

High

692130

MARK3
MAP/microtubule affinity-regulating kinase 3

1

1

High-throughput

0.494

High

942875

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.494

High

167392

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

474976

VIME
Vimentin

1

0

High-throughput

0.493

High

280954

HYPM
Huntingtin-interacting protein M

1

1

High-throughput

0.489

High

370360

CYTA
Cystatin-A

1

1

High-throughput

0.489

High

686863

S10A4
Protein S100-A4

1

2

High-throughput

0.489

High

1122339

SCRIB
Protein scribble homolog

1

1

High-throughput

0.489

High

1169432

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

1

1

High-throughput

0.489

High

1272087

BOP
Protein Bop

1

1

High-throughput

0.489

High

1316293

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.489

High

1328122

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.489

High

1367903

THRSP
Thyroid hormone-inducible hepatic protein

1

3

High-throughput

0.489

High

1415075

LRC61
Leucine-rich repeat-containing protein 61

1

1

High-throughput

0.489

High

1431596

M1IP1
Mid1-interacting protein 1

1

3

High-throughput

0.489

High

1431605

CC018
Uncharacterized protein C3orf18

1

3

High-throughput

0.489

High

1219339

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

Small-scale

0.481

High

412591

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

631466

RAB5A
Ras-related protein Rab-5A

1

15

High-throughput

0.479

High

902062

RAB9A
Ras-related protein Rab-9A

1

15

High-throughput

0.479

High

976553

RB11A
Ras-related protein Rab-11A

1

5

Small-scale

0.479

High

1255497

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1367247

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1383404

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

3

High-throughput

0.479

High

1413310

DIDO1
Death-inducer obliterator 1

1

1

High-throughput

0.479

High

1431602

UVRAG
UV radiation resistance-associated gene protein

1

3

Small-scale

0.479

High

1431604

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

274748

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.470

High

374921

RASH
GTPase HRas

1

4

High-throughput

0.470

High

442470

GELS
Gelsolin

1

1

High-throughput

0.470

High

593790

PECA1
Platelet endothelial cell adhesion molecule

1

1

High-throughput

0.470

High

650407

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.470

High

178046

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

4

High-throughput

0.464

High

1271335

MON1B
Vacuolar fusion protein MON1 homolog B

1

8

Small-scale

0.464

High

1394962

ZN469
Zinc finger protein 469

1

0

High-throughput

0.458

High

949998

KR103
Keratin-associated protein 10-3

1

2

High-throughput

0.439

High

1087545

GRSF1
G-rich sequence factor 1

1

1

Small-scale

0.439

High

106637

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

942355

BACE1
Beta-secretase 1

1

0

Small-scale

0.426

High

62594

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

653564

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

669209

EDNRA
Endothelin-1 receptor

1

3

Small-scale

0.407

High

1357488

LTO1
Protein LTO1 homolog

1

1

High-throughput

0.407

High

1384958

CC127
Coiled-coil domain-containing protein 127

1

2

High-throughput

0.407

High

1431597

PARVA
Alpha-parvin

3

0

High-throughput

0.347

High

552899

RLBP1
Retinaldehyde-binding protein 1

1

0

High-throughput

0.279

Low

1005961

GTF2I
General transcription factor II-I

1

0

High-throughput

0.279

Low

1199976

CCD92
Coiled-coil domain-containing protein 92

1

0

High-throughput

0.279

Low

1258843

CYS1
Cystin-1

1

0

High-throughput

0.279

Low

1431595

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.279

Low

1431600

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

0

High-throughput

0.279

Low

702500

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.268

Low

1279741

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.268

Low

1431608

Q9Y649
GW128

1

0

High-throughput

0.268

Low

246940

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.265

Low

1363185

AP2B
Transcription factor AP-2-beta

1

0

High-throughput

0.238

Low

337139

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.232

Low

1431607

NPTN
Neuroplastin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025