HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TRIM8 (Q9BZR9)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	33163282
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0051091 - positive regulation of DNA-binding transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 551
+	Hs
		370187 ESR1_HUMAN (1-595): 0: 599: 100.00		TRI11_HUMAN (2-522): 2.8e-82: 266: 15.49
+	Hs
		368914 ESR1_HUMAN (1-595): 0: 599: 100.00		TRI27_HUMAN (1-531): 9.22e-71: 237: 12.63
+	Hs
		262145 ESR1_HUMAN (1-595): 0: 599: 100.00		TRIM3_HUMAN (10-483): 1.51e-63: 223: 14.96
+	Hs
		370719 ESR1_HUMAN (1-595): 0: 599: 100.00		TRI33_HUMAN (14-534): 5.05e-61: 220: 14.95
+	Hs
		369597 ESR1_HUMAN (1-595): 0: 599: 100.00		TRI25_HUMAN (8-365): 1.14e-59: 210: 22.31
+	Hs
		369497 ESR1_HUMAN (1-595): 0: 599: 100.00		TRI26_HUMAN (1-412): 2.24e-59: 207: 16.39
+	Hs
		170202 ESR1_HUMAN (1-595): 0: 599: 100.00		TIF1A_HUMAN (14-531): 9.28e-53: 195: 14.06
+	Hs
		370324 ESR1_HUMAN (1-595): 0: 599: 100.00		TRI56_HUMAN (13-261): 5.59e-42: 162: 26.64
+	Hs
		175702 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TRI18_HUMAN (6-463): 2.85e-71: 242: 16.80
+	Hs
		536957 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TRI27_HUMAN (1-531): 9.22e-71: 237: 12.63
+	Hs
		1269940 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TRI33_HUMAN (14-534): 5.05e-61: 220: 14.95
+	Hs
		1052721 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TRI25_HUMAN (8-365): 1.14e-59: 210: 22.31
+	Hs
		1019345 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TRI26_HUMAN (1-412): 2.24e-59: 207: 16.39
+	Hs
		170435 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIF1A_HUMAN (14-531): 9.28e-53: 195: 14.06
+	Hs
		1269384 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TRI47_HUMAN (13-298): 2.05e-50: 185: 21.28
+	Hs
		782695 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TRI33_HUMAN (14-534): 5.05e-61: 220: 14.95
+	Hs
		170251 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		TIF1A_HUMAN (14-531): 9.28e-53: 195: 14.06
+	Hs
		1269484 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TRI56_HUMAN (13-261): 5.59e-42: 162: 26.64
+	Hs
		170289 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TIF1A_HUMAN (14-531): 9.28e-53: 195: 14.06
+	Hs
		170205 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TIF1A_HUMAN (14-531): 9.28e-53: 195: 14.06