Protein: CYTB
Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B)

Gene: CYTB, CSTB
Organism: Homo sapiens
Interactions: 96
UniProt ID: P04080

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0003723 - RNA binding
GO:0004866 - endopeptidase inhibitor activity
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402741

CATB
Cathepsin B

3

7

Small-scale

0.840

High

402742

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

2

6

Small-scale

0.799

High

402740

CATL1
Procathepsin L

1

6

High-throughput

0.691

High

402755

CATO
Cathepsin O

1

8

High-throughput

0.691

High

402806

CATF
Cathepsin F

1

8

High-throughput

0.691

High

402737

CYTB
Cystatin-B

1

1

Small-scale

0.647

High

370026

CYTC
Cystatin-C

1

0

Small-scale

0.614

High

402810

TN13B
Tumor necrosis factor ligand superfamily member 13B

3

0

High-throughput

0.613

High

402746

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

402795

LGMN
Legumain

1

1

Small-scale

0.575

High

402775

RHG31
Rho GTPase-activating protein 31

2

1

High-throughput

0.571

High

402802

RHG35
Rho GTPase-activating protein 35

2

2

High-throughput

0.571

High

402762

H31
Histone H3.1

2

0

Small-scale

0.559

High

180653

TIF1A
Transcription intermediary factor 1-alpha

1

3

High-throughput

0.536

High

402768

CUL3
Cullin-3

1

2

High-throughput

0.536

High

402785

PDK1L
Serine/threonine-protein kinase PDIK1L

1

1

High-throughput

0.536

High

402809

AURKC
Aurora kinase C

1

1

High-throughput

0.536

High

402752

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.515

High

402751

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

High-throughput

0.513

High

402792

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

402805

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

High-throughput

0.513

High

221076

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.508

High

238345

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.508

High

402754

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

402765

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

0

High-throughput

0.493

High

402801

ECT2
Protein ECT2

1

3

High-throughput

0.481

High

259286

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

370887

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

402738

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

402747

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

402756

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

402767

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

402771

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

402776

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

402777

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

402788

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

402790

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

402794

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

402800

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

402812

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

65520

DDTL
D-dopachrome decarboxylase-like protein

1

0

High-throughput

0.458

High

125133

LEG9
Galectin-9

1

0

High-throughput

0.458

High

240454

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

276747

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.458

High

319281

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324392

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

347455

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

375071

RASK
GTPase KRas

1

0

High-throughput

0.458

High

377349

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

379827

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

402744

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

402745

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

402748

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

402749

PTBP1
Polypyrimidine tract-binding protein 1

1

0

High-throughput

0.458

High

402750

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

0

High-throughput

0.458

High

402753

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.458

High

402757

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.458

High

402758

MTPN
Myotrophin

1

0

High-throughput

0.458

High

402759

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

402760

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

402761

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

402763

CYC
Cytochrome c

1

0

High-throughput

0.458

High

402764

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

402766

PRDM2
PR domain zinc finger protein 2

1

0

High-throughput

0.458

High

402769

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

402770

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

402772

PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

1

0

High-throughput

0.458

High

402773

CCDC6
Coiled-coil domain-containing protein 6

1

0

High-throughput

0.458

High

402774

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

402779

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

402780

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

402781

DET1
DET1 homolog

1

0

High-throughput

0.458

High

402782

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

402786

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.458

High

402787

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

402789

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

0

High-throughput

0.458

High

402791

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

402793

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

402796

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.458

High

402797

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.458

High

402803

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

402804

NRK1
Nicotinamide riboside kinase 1

1

0

High-throughput

0.458

High

402807

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

402808

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

327722

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

402739

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

402798

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

402799

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

High-throughput

0.445

High

217696

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

402784

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.437

High

213034

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

402743

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

402778

LIN54
Protein lin-54 homolog

1

0

Small-scale

0.426

High

402783

NAV3
Neuron navigator 3

1

0

High-throughput

0.249

Low

402811

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025