HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: M3K20 (Q9NYL2)
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
Gene: MAP3K20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 800
+	Hs
		1269777 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		M3K20_HUMAN (1-800): 0: 1246: 100.00
+	Hs
		368834 ESR1_HUMAN (1-595): 0: 599: 100.00		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		1083515 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		M3K11_HUMAN (12-331): 1.29e-112: 364: 37.01
+	Hs
		433435 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		487203 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		337320 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85
+	Hs
		433225 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		YES_HUMAN (2-268): 9.65e-100: 321: 29.86