Protein: AQP1
Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel)

Gene: AQP1
Organism: Homo sapiens
Interactions: 145
UniProt ID: P29972

Gene Ontology (top 5):
GO:0003091 - renal water homeostasis
GO:0003094 - glomerular filtration
GO:0003097 - renal water transport
GO:0005223 - intracellularly cGMP-activated cation channel activity
GO:0005267 - potassium channel activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

715876

AQP1
Aquaporin-1

4

18

Small-scale

0.904

High

715894

AQP6
Aquaporin-6

2

18

High-throughput

0.783

High

715947

MDFI
MyoD family inhibitor

6

1

High-throughput

0.738

High

715897

TRIP6
Thyroid receptor-interacting protein 6

4

1

High-throughput

0.705

High

715878

TRI23
E3 ubiquitin-protein ligase TRIM23

3

4

High-throughput

0.675

High

715906

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

2

High-throughput

0.675

High

715976

RGS17
Regulator of G-protein signaling 17

3

1

High-throughput

0.675

High

715979

IKZF3
Zinc finger protein Aiolos

3

3

High-throughput

0.675

High

715885

REL
Proto-oncogene c-Rel

3

3

High-throughput

0.650

High

230267

CREB3
Cyclic AMP-responsive element-binding protein 3

2

4

High-throughput

0.640

High

715920

NT2NA
Notch homolog 2 N-terminal-like protein A

2

2

High-throughput

0.633

High

715954

KRA42
Keratin-associated protein 4-2

3

10

High-throughput

0.616

High

138553

CLD5
Claudin-5

2

4

High-throughput

0.606

High

188820

TMPS2
Transmembrane protease serine 2

2

1

High-throughput

0.606

High

300632

KRT37
Keratin, type I cuticular Ha7

2

5

High-throughput

0.606

High

323194

TRI37
E3 ubiquitin-protein ligase TRIM37

2

1

High-throughput

0.606

High

332784

KCNK5
Potassium channel subfamily K member 5

2

1

High-throughput

0.606

High

590247

MUC1
Mucin-1

2

2

High-throughput

0.606

High

715879

COMP
Cartilage oligomeric matrix protein

2

1

High-throughput

0.606

High

715899

S15A2
Solute carrier family 15 member 2

2

5

High-throughput

0.606

High

715902

ZN792
Zinc finger protein 792

2

2

High-throughput

0.606

High

715907

F209A
Protein FAM209A

2

2

High-throughput

0.606

High

715913

TENS2
Tensin-2

2

3

High-throughput

0.606

High

715921

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

2

3

High-throughput

0.606

High

715922

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

2

3

High-throughput

0.606

High

715940

LRC59
Leucine-rich repeat-containing protein 59

2

6

High-throughput

0.606

High

715958

TRIM7
E3 ubiquitin-protein ligase TRIM7

2

1

High-throughput

0.606

High

715960

PRD14
PR domain zinc finger protein 14

2

2

High-throughput

0.606

High

715965

S39A2
Zinc transporter ZIP2

2

3

High-throughput

0.606

High

715968

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

2

High-throughput

0.606

High

70128

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

72405

MI4GD
MIF4G domain-containing protein

2

0

High-throughput

0.580

High

129850

GET1
Guided entry of tail-anchored proteins factor 1

2

0

High-throughput

0.580

High

186245

SIVA
Apoptosis regulatory protein Siva

2

0

High-throughput

0.580

High

253938

LPXN
Leupaxin

2

0

High-throughput

0.580

High

258634

G37L1
G-protein coupled receptor 37-like 1

2

0

High-throughput

0.580

High

284652

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

2

0

High-throughput

0.580

High

332487

CCDB1
Cyclin-D1-binding protein 1

2

0

High-throughput

0.580

High

343738

LDOC1
Protein LDOC1

2

0

High-throughput

0.580

High

466631

GLI1
Zinc finger protein GLI1

2

0

High-throughput

0.580

High

549736

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.580

High

599970

ZNF16
Zinc finger protein 16

2

0

High-throughput

0.580

High

715877

EVI2B
Protein EVI2B

2

0

High-throughput

0.580

High

715884

CDR2
Cerebellar degeneration-related protein 2

2

0

High-throughput

0.580

High

715891

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.580

High

715908

SPDYA
Speedy protein A

2

0

High-throughput

0.580

High

715917

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.580

High

715923

CPLX4
Complexin-4

2

0

High-throughput

0.580

High

715928

IFT20
Intraflagellar transport protein 20 homolog

2

0

High-throughput

0.580

High

715933

ZN398
Zinc finger protein 398

2

0

High-throughput

0.580

High

715944

BMF
Bcl-2-modifying factor

2

0

High-throughput

0.580

High

715945

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

715949

BEGIN
Brain-enriched guanylate kinase-associated protein

2

0

High-throughput

0.580

High

715950

B2L13
Bcl-2-like protein 13

2

0

High-throughput

0.580

High

715961

GO45
Golgin-45

2

0

High-throughput

0.580

High

715963

RN122
RING finger protein 122

2

0

High-throughput

0.580

High

715964

IL21R
Interleukin-21 receptor

2

0

High-throughput

0.580

High

715970

PLS2
Phospholipid scramblase 2

2

0

High-throughput

0.580

High

715971

TM38B
Trimeric intracellular cation channel type B

2

0

High-throughput

0.580

High

715973

RBAK
RB-associated KRAB zinc finger protein

2

0

High-throughput

0.580

High

715974

ZIM2
Zinc finger imprinted 2

2

0

High-throughput

0.580

High

51399

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

4

High-throughput

0.573

High

221086

SPY2
Protein sprouty homolog 2

1

3

High-throughput

0.573

High

303107

RGS20
Regulator of G-protein signaling 20

1

1

High-throughput

0.573

High

715888

ACK1
Activated CDC42 kinase 1

1

1

High-throughput

0.573

High

715890

TRAF2
TNF receptor-associated factor 2

1

3

High-throughput

0.573

High

715892

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.573

High

715895

KT33B
Keratin, type I cuticular Ha3-II

1

5

High-throughput

0.573

High

715896

K1H1
Keratin, type I cuticular Ha1

1

5

High-throughput

0.573

High

715900

CCD57
Coiled-coil domain-containing protein 57

1

2

High-throughput

0.573

High

715967

CRAC1
Cartilage acidic protein 1

1

2

High-throughput

0.573

High

715975

RIM3A
RIMS-binding protein 3A

1

2

High-throughput

0.573

High

715977

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

6

High-throughput

0.573

High

715978

IKZF2
Zinc finger protein Helios

1

2

High-throughput

0.573

High

166869

MGST3
Glutathione S-transferase 3, mitochondrial

2

3

High-throughput

0.553

High

176289

ZBT39
Zinc finger and BTB domain-containing protein 39

2

1

High-throughput

0.553

High

221409

SPY3
Protein sprouty homolog 3

2

3

High-throughput

0.553

High

335230

CXB5
Gap junction beta-5 protein

2

4

High-throughput

0.553

High

665914

IBP6
Insulin-like growth factor-binding protein 6

2

2

High-throughput

0.553

High

715883

KR108
Keratin-associated protein 10-8

2

9

High-throughput

0.553

High

715886

KRA11
Keratin-associated protein 1-1

2

9

High-throughput

0.553

High

715889

GOGA2
Golgin subfamily A member 2

2

3

High-throughput

0.553

High

715909

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

2

1

High-throughput

0.553

High

715916

MRM1
rRNA methyltransferase 1, mitochondrial

2

2

High-throughput

0.553

High

715927

TRI42
Tripartite motif-containing protein 42

2

4

High-throughput

0.553

High

715934

GPX8
Probable glutathione peroxidase 8

2

2

High-throughput

0.553

High

715935

TRI41
E3 ubiquitin-protein ligase TRIM41

2

2

High-throughput

0.553

High

715936

SSMM1
Serine-rich single-pass membrane protein 1

2

1

High-throughput

0.553

High

715951

KRA98
Keratin-associated protein 9-8

2

10

High-throughput

0.553

High

715953

KRA44
Keratin-associated protein 4-4

2

10

High-throughput

0.553

High

715956

KRA15
Keratin-associated protein 1-5

2

10

High-throughput

0.553

High

715969

SAR1A
Small COPII coat GTPase SAR1A

2

5

High-throughput

0.553

High

587010

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

715926

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

0

High-throughput

0.549

High

715946

CSRN1
Cysteine/serine-rich nuclear protein 1

1

0

High-throughput

0.549

High

351507

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

1

High-throughput

0.541

High

715930

KCD17
BTB/POZ domain-containing protein KCTD17

1

2

High-throughput

0.541

High

715882

KR107
Keratin-associated protein 10-7

1

9

High-throughput

0.523

High

715914

K1C40
Keratin, type I cytoskeletal 40

1

5

High-throughput

0.523

High

715919

KCTD9
BTB/POZ domain-containing protein KCTD9

1

2

High-throughput

0.523

High

715943

CC136
Coiled-coil domain-containing protein 136

1

2

High-throughput

0.523

High

715952

KRA92
Keratin-associated protein 9-2

1

10

High-throughput

0.523

High

715898

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

715939

RN166
E3 ubiquitin-protein ligase RNF166

1

1

High-throughput

0.515

High

715980

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

4

High-throughput

0.515

High

715915

Q6FG41
Protein c-Fos

1

5

High-throughput

0.515

High

715948

KR412
Keratin-associated protein 4-12

1

10

High-throughput

0.494

High

485

NBPFJ
NBPF family member NBPF19

1

1

High-throughput

0.481

High

370579

FOS
Protein c-Fos

1

5

High-throughput

0.481

High

385481

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.481

High

715904

AMOT
Angiomotin

1

2

High-throughput

0.481

High

715911

NBPF6
NBPF family member NBPF6

1

1

High-throughput

0.481

High

715937

TSC1
Hamartin

1

1

High-throughput

0.481

High

535924

MYH3
Myosin-3

1

1

Small-scale

0.479

High

59906

A2BDD9
AMOT protein

1

1

High-throughput

0.470

High

516970

NT2NC
Notch homolog 2 N-terminal-like protein C

1

2

High-throughput

0.470

High

715924

Q86WV8
TSC complex subunit 1

1

1

High-throughput

0.470

High

715887

PPARA
Peroxisome proliferator-activated receptor alpha

1

0

High-throughput

0.460

High

715925

NUTM1
NUT family member 1

1

0

High-throughput

0.460

High

550865

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

715893

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.457

High

715957

TRI54
Tripartite motif-containing protein 54

1

3

High-throughput

0.457

High

715881

KR103
Keratin-associated protein 10-3

1

9

High-throughput

0.439

High

715938

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

47259

A0A6Q8KRG2
Golgin subfamily A member 2

1

3

High-throughput

0.417

High

715959

CEP44
Centrosomal protein of 44 kDa

2

0

High-throughput

0.327

High

715918

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.323

High

192063

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.316

High

561207

MYF5
Myogenic factor 5

2

0

High-throughput

0.316

High

715880

KR124
Keratin-associated protein 12-4

2

0

High-throughput

0.316

High

715901

F161A
Protein FAM161A

2

0

High-throughput

0.316

High

715903

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

715905

KLH26
Kelch-like protein 26

2

0

High-throughput

0.316

High

715910

LCE1A
Late cornified envelope protein 1A

2

0

High-throughput

0.316

High

715912

SPRY7
SPRY domain-containing protein 7

2

0

High-throughput

0.316

High

715932

FNDC9
Fibronectin type III domain-containing protein 9

2

0

High-throughput

0.316

High

715941

TM45B
Transmembrane protein 45B

2

0

High-throughput

0.316

High

715942

TMM80
Transmembrane protein 80

2

0

High-throughput

0.316

High

715955

KRA32
Keratin-associated protein 3-2

2

0

High-throughput

0.316

High

715962

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.316

High

715966

ESM1
Endothelial cell-specific molecule 1

2

0

High-throughput

0.316

High

715972

PGPI
Pyroglutamyl-peptidase 1

2

0

High-throughput

0.316

High

715929

IHO1
Interactor of HORMAD1 protein 1

1

0

High-throughput

0.299

High

715931

K1958
Uncharacterized protein KIAA1958

1

0

High-throughput

0.299

High


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Last updated: 11Aug2025