HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TBL2 (Q9Y4P3)
Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein)
Gene: TBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	31527615, 33731348, 21182205, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 447
+	Hs
		369932 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5B_HUMAN (165-446): 3.24e-66: 216: 15.28
+	Hs
		369488 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL3_HUMAN (12-447): 1.29e-58: 207: 13.88
+	Hs
		370377 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1R_HUMAN (3-260): 1.52e-55: 193: 11.40
+	Hs
		369669 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF5_HUMAN (233-445): 1.36e-31: 130: 18.07
+	Hs
		369305 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5_HUMAN (4-165): 6.22e-31: 123: 8.93
+	Hs
		267731 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF5L_HUMAN (76-247): 1.76e-26: 114: 15.76
+	Hs
		369362 ESR1_HUMAN (1-595): 0: 599: 100.00		RACK1_HUMAN (266-445): 3.22e-20: 92.7: 16.30
+	Hs
		1016308 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL3_HUMAN (12-447): 1.29e-58: 207: 13.88
+	Hs
		1269548 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1R_HUMAN (3-260): 1.52e-55: 193: 11.40
+	Hs
		377280 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TBL3_HUMAN (12-447): 1.29e-58: 207: 13.88
+	Hs
		1074801 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAF5_HUMAN (233-445): 1.36e-31: 130: 18.07
+	Hs
		903403 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		WDR5_HUMAN (4-165): 6.22e-31: 123: 8.93
+	Hs
		245574 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TBL1X_HUMAN (3-260): 4.69e-45: 166: 13.36
+	Hs
		267782 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAF5L_HUMAN (76-247): 1.76e-26: 114: 15.76
+	Hs
		929598 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RACK1_HUMAN (266-445): 3.22e-20: 92.7: 16.30
+	Hs
		1269746 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NLE1_HUMAN (356-445): 8.01e-19: 90.6: 15.56
+	Hs
		782550 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TAF5_HUMAN (233-445): 1.36e-31: 130: 18.07
+	Hs
		782513 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		WDR5_HUMAN (4-165): 6.22e-31: 123: 8.93
+	Hs
		267744 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		TAF5L_HUMAN (76-247): 1.76e-26: 114: 15.76
+	Hs
		377234 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		RACK1_HUMAN (266-445): 3.22e-20: 92.7: 16.30