HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: PRDX3 (P30048)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Gene: PRDX3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0008284 - positive regulation of cell population proliferation GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 256
+	Hs
		371291 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		PRDX2_HUMAN (58-255): 2.08e-104: 302: 63.13
+	Hs
		371922 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		PRDX4_HUMAN (35-255): 3.39e-103: 302: 58.82
+	Hs
		371848 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54
+	Hs
		371258 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		PRDX6_HUMAN (63-254): 3.42e-68: 211: 25.25
+	Hs
		405822 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		PRDX3_HUMAN (1-256): 3.49e-122: 349: 100.00
+	Hs
		405836 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		PRDX2_HUMAN (58-255): 2.08e-104: 302: 63.13
+	Hs
		406131 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		PRDX4_HUMAN (35-255): 3.39e-103: 302: 58.82
+	Hs
		406095 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54
+	Hs
		405821 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		PRDX6_HUMAN (63-254): 3.42e-68: 211: 25.25