HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: RALB (P11234)
Ras-related protein Ral-B (EC 3.6.5.2)
Gene: RALB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38496616
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0007165 - signal transduction GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 206
+	Hs
		373597 RAF1_HUMAN (1-648): 0: 652: 100.00		RALA_HUMAN (1-206): 1.04e-86: 256: 81.64
+	Hs
		373973 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB8A_HUMAN (8-206): 2.64e-81: 242: 29.81
+	Hs
		374007 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1A_HUMAN (5-204): 2.25e-81: 242: 31.07
+	Hs
		373978 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB10_HUMAN (9-204): 3.13e-81: 241: 29.65
+	Hs
		374854 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1B_HUMAN (7-204): 1.59e-80: 240: 30.05
+	Hs
		373980 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB14_HUMAN (1-199): 1.59e-75: 228: 30.00
+	Hs
		374003 RAF1_HUMAN (1-648): 0: 652: 100.00		RB11A_HUMAN (5-204): 1.06e-75: 228: 29.44
+	Hs
		374009 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP1A_HUMAN (15-183): 1e-50: 164: 48.82
+	Hs
		373983 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP1B_HUMAN (15-193): 4e-50: 162: 47.78
+	Hs
		349052 RAF1_HUMAN (1-648): 0: 652: 100.00		RASH_HUMAN (27-181): 3.76e-49: 160: 52.90
+	Hs
		348461 RAF1_HUMAN (1-648): 0: 652: 100.00		RASN_HUMAN (27-191): 8.77e-49: 159: 50.00
+	Rn
		507685 RAF1_RAT (1-648): 0: 648: 98.30		RASH_RAT (27-181): 3.76e-49: 160: 52.90
+	Mm
		1142565 RAF1_MOUSE (1-648): 0: 647: 97.69		RASH_MOUSE (27-181): 3.76e-49: 160: 52.90
+	Hs
		349785 RAF1_HUMAN (1-648): 0: 652: 100.00		RASK_HUMAN (27-198): 2.81e-47: 155: 50.00
+	Hs
		373993 RAF1_HUMAN (1-648): 0: 652: 100.00		RRAS2_HUMAN (27-206): 3.88e-46: 152: 46.67
+	Rn
		442943 RAF1_RAT (1-648): 0: 648: 98.30		RASK_RAT (27-198): 4.15e-47: 154: 50.00
+	Mm
		699624 RAF1_MOUSE (1-648): 0: 647: 97.69		RASK_MOUSE (27-198): 4.15e-47: 154: 50.00
+	Hs
		349101 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RASH_HUMAN (27-181): 3.76e-49: 160: 52.90
+	Hs
		348493 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RASN_HUMAN (27-191): 8.77e-49: 159: 50.00
+	Hs
		349847 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RASK_HUMAN (27-198): 2.81e-47: 155: 50.00