Protein: SHOC2
Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog)

Gene: SHOC2
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9UQ13

Gene Ontology (top 5):
GO:0000164 - protein phosphatase type 1 complex
GO:0005225 - volume-sensitive anion channel activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

968040

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

6

17

High-throughput

0.945

High

786937

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

6

17

High-throughput

0.943

High

401711

RAF1
RAF proto-oncogene serine/threonine-protein kinase

4

20

Small-scale

0.881

High

375021

RASH
GTPase HRas

3

15

Small-scale

0.878

High

376105

RASK
GTPase KRas

2

17

Small-scale

0.775

High

165132

RASM
Ras-related protein M-Ras

2

9

Small-scale

0.754

High

1401957

ERBIN
Erbin

1

18

Small-scale

0.715

High

968489

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

17

High-throughput

0.691

High

1280608

HUWE1
E3 ubiquitin-protein ligase HUWE1

3

2

Small-scale

0.669

High

409541

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

2

High-throughput

0.659

High

521050

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

2

High-throughput

0.659

High

1462651

SHOC2
Leucine-rich repeat protein SHOC-2

1

20

High-throughput

0.618

High

296079

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

2

1

High-throughput

0.571

High

365493

PGK1
Phosphoglycerate kinase 1

2

1

High-throughput

0.571

High

403039

ANXA1
Annexin A1

2

1

High-throughput

0.571

High

415939

HSPB1
Heat shock protein beta-1

2

1

High-throughput

0.571

High

466067

ANXA6
Annexin A6

2

1

High-throughput

0.571

High

469347

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

2

1

High-throughput

0.571

High

489121

ALDOC
Fructose-bisphosphate aldolase C

2

1

High-throughput

0.571

High

567524

TCTP
Translationally-controlled tumor protein

2

1

High-throughput

0.571

High

577926

PLAK
Junction plakoglobin

2

9

High-throughput

0.571

High

716466

PRDX5
Peroxiredoxin-5, mitochondrial

2

1

High-throughput

0.571

High

730359

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.571

High

954642

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

1

High-throughput

0.571

High

972139

1433E
14-3-3 protein epsilon

2

8

High-throughput

0.571

High

1108754

TBB3
Tubulin beta-3 chain

2

2

High-throughput

0.571

High

1462652

SGT1
Protein SGT1 homolog

2

18

High-throughput

0.571

High

1371784

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.561

High

1380256

FBXW7
F-box/WD repeat-containing protein 7

1

6

Small-scale

0.561

High

969086

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.549

High

361828

PNPH
Purine nucleoside phosphorylase

2

0

High-throughput

0.547

High

542817

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

0

High-throughput

0.547

High

728980

PUR9
Bifunctional purine biosynthesis protein ATIC

2

0

High-throughput

0.547

High

1048337

LGUL
Lactoylglutathione lyase

2

0

High-throughput

0.547

High

1152301

MARE1
Microtubule-associated protein RP/EB family member 1

2

0

High-throughput

0.547

High

1449602

OLA1
Obg-like ATPase 1

2

0

High-throughput

0.547

High

373515

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.536

High

421206

ALDOB
Fructose-bisphosphate aldolase B

1

1

High-throughput

0.536

High

854388

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

1111368

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1448570

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

426599

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

186125

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

423469

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

397237

ESR1
Estrogen receptor

1

12

High-throughput

0.500

High

596427

H12
Histone H1.2

1

0

High-throughput

0.493

High

943431

H2BFS
Histone H2B type F-S

1

0

High-throughput

0.493

High

1324733

CBARP
Voltage-dependent calcium channel beta subunit-associated regulatory protein

1

1

High-throughput

0.489

High

572282

TRI27
Zinc finger protein RFP

1

4

Small-scale

0.479

High

839406

MTOR
Serine/threonine-protein kinase mTOR

1

3

Small-scale

0.479

High

935304

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

967187

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

2

Small-scale

0.479

High

1067845

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1163673

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

3

High-throughput

0.479

High

1256125

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1322676

RPTOR
Regulatory-associated protein of mTOR

1

6

Small-scale

0.479

High

1367605

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

1386633

OPTN
Optineurin

1

9

High-throughput

0.479

High

1462551

PLCL2
Inactive phospholipase C-like protein 2

1

2

High-throughput

0.479

High

1431345

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

530596

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

76590

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

10

High-throughput

0.437

High

1328773

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

5

Small-scale

0.437

High

1357840

S35F5
Solute carrier family 35 member F5

1

1

High-throughput

0.437

High

1415954

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.426

High

362078

AATM
Aspartate aminotransferase, mitochondrial

2

0

High-throughput

0.298

High

882950

EFTU
Elongation factor Tu, mitochondrial

2

0

High-throughput

0.298

High

1454001

TM14C
Transmembrane protein 14C

2

0

High-throughput

0.298

High


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Last updated: 11Aug2025