HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 216
+	Hs
		374007 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00
+	Hs
		374854 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1B_HUMAN (4-195): 1.12e-80: 240: 28.72
+	Hs
		373973 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB8A_HUMAN (1-203): 1.27e-79: 238: 24.76
+	Hs
		374003 RAF1_HUMAN (1-648): 0: 652: 100.00		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Hs
		373978 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB10_HUMAN (11-177): 3.9e-29: 109: 33.14
+	Hs
		373902 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13
+	Hs
		373665 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB4A_HUMAN (11-169): 1.53e-27: 105: 34.57
+	Hs
		374489 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB43_HUMAN (11-169): 1.85e-27: 105: 38.24
+	Hs
		542851 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00
+	Gg
		787859 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		RAN_CHICK (1-216): 1.73e-79: 238: 98.61
+	Mm
		655940 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		RAN_MOUSE (1-216): 7.75e-79: 237: 100.00
+	Hs
		488656 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		488650 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Hs
		433358 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19
+	Hs
		522882 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Hs
		433312 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Hs
		412121 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00