HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 25852190, 28205554, 31980649, 7628630, 10620507, 35271311, 32707033, 38496616, 16041367, 12861023, 9261098, 10887173, 10611249, 36931259, 22222486, 11697890, 9632690, 15664191, 16093354, 7935795 and 12 others

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Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, pull down, proximity labelling technology, two hybrid, anti tag coimmunoprecipitation, surface plasmon resonance, x-ray crystallography, lex-a dimerization assay, tandem affinity purification and 3 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains 14-3-3~C1_1
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006468 - protein phosphorylation
GO:0007165 - signal transduction
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024