Protein: GLI1
Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)

Gene: GLI1
Organism: Homo sapiens
Interactions: 119
UniProt ID: P08151

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

436681

KPCI
Protein kinase C iota type

2

3

Small-scale

0.825

High

436666

CDK4
Cyclin-dependent kinase 4

2

7

Small-scale

0.812

High

436760

SUFU
Suppressor of fused homolog

17

11

Small-scale

0.766

High

436705

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

2

3

Small-scale

0.754

High

158373

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

4

Small-scale

0.747

High

436674

KS6B1
Ribosomal protein S6 kinase beta-1

1

5

Small-scale

0.747

High

436692

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

3

High-throughput

0.740

High

436717

ZIC1
Zinc finger protein ZIC 1

1

16

Small-scale

0.724

High

436748

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

2

Small-scale

0.724

High

436763

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

1

Small-scale

0.724

High

436752

STK36
Serine/threonine-protein kinase 36

1

6

Small-scale

0.665

High

436671

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

Small-scale

0.647

High

436743

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

4

Small-scale

0.641

High

436709

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

3

0

Small-scale

0.641

High

436738

KAT2B
Histone acetyltransferase KAT2B

3

11

Small-scale

0.640

High

436762

FBW1A
F-box/WD repeat-containing protein 1A

3

10

Small-scale

0.640

High

436726

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

10

Small-scale

0.624

High

167448

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

5

Small-scale

0.618

High

313635

ZIC2
Zinc finger protein ZIC 2

1

18

Small-scale

0.618

High

414688

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.618

High

436665

GLI3
Transcriptional activator GLI3

1

18

Small-scale

0.618

High

436722

MARK2
Serine/threonine-protein kinase MARK2

1

1

Small-scale

0.618

High

436744

ZN521
Zinc finger protein 521

1

8

Small-scale

0.618

High

436746

SRPK1
SRSF protein kinase 1

1

6

Small-scale

0.618

High

436710

HDAC1
Histone deacetylase 1

2

11

Small-scale

0.584

High

436677

AQP1
Aquaporin-1

2

0

High-throughput

0.580

High

436663

GLI1
Zinc finger protein GLI1

1

18

High-throughput

0.575

High

436741

GCC1
GRIP and coiled-coil domain-containing protein 1

1

6

High-throughput

0.573

High

436686

NUMB
Protein numb homolog

1

3

Small-scale

0.561

High

436701

TCPB
T-complex protein 1 subunit beta

1

2

Small-scale

0.561

High

436718

TAF9
Transcription initiation factor TFIID subunit 9

1

2

Small-scale

0.561

High

436749

ANM1
Protein arginine N-methyltransferase 1

1

7

Small-scale

0.561

High

436750

MEP50
Methylosome protein WDR77

1

3

Small-scale

0.561

High

436757

FEM1B
Protein fem-1 homolog B

1

5

Small-scale

0.561

High

436727

THOC4
THO complex subunit 4

2

0

Small-scale

0.559

High

436724

RAI1
Retinoic acid-induced protein 1

1

2

High-throughput

0.541

High

436712

RUNX3
Runt-related transcription factor 3

1

0

Small-scale

0.537

High

385942

P53
Cellular tumor antigen p53

1

6

High-throughput

0.536

High

436669

TRI27
Zinc finger protein RFP

1

10

High-throughput

0.536

High

436672

DESM
Desmin

1

11

High-throughput

0.536

High

436682

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.536

High

436688

FXR1
RNA-binding protein FXR1

1

5

High-throughput

0.536

High

436690

SMCA4
Transcription activator BRG1

1

8

High-throughput

0.536

High

436713

ZMYM3
Zinc finger MYM-type protein 3

1

6

High-throughput

0.536

High

436719

KIF7
Kinesin-like protein KIF7

1

5

High-throughput

0.536

High

436721

CRACD
Capping protein-inhibiting regulator of actin dynamics

1

5

High-throughput

0.536

High

436733

SMRC2
SWI/SNF complex subunit SMARCC2

1

4

High-throughput

0.536

High

436734

SNX33
Sorting nexin-33

1

2

High-throughput

0.536

High

436735

IFT81
Intraflagellar transport protein 81 homolog

1

5

High-throughput

0.536

High

436739

RAD50
DNA repair protein RAD50

1

6

High-throughput

0.536

High

436745

IFT74
Intraflagellar transport protein 74 homolog

1

4

High-throughput

0.536

High

436679

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.534

High

436728

TRI42
Tripartite motif-containing protein 42

1

20

High-throughput

0.523

High

436673

XBP1
X-box-binding protein 1

1

0

High-throughput

0.518

High

47918

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.513

High

436687

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.513

High

436753

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.513

High

153541

ANM5
Protein arginine N-methyltransferase 5

1

6

Small-scale

0.501

High

436668

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.489

High

195319

DHX15
ATP-dependent RNA helicase DHX15

1

2

Small-scale

0.479

High

209379

PLRG1
Pleiotropic regulator 1

1

6

Small-scale

0.479

High

211106

BUB3
Mitotic checkpoint protein BUB3

1

3

Small-scale

0.479

High

312163

IPO7
Importin-7

1

20

Small-scale

0.479

High

408977

K2C8
Keratin, type II cytoskeletal 8

1

4

Small-scale

0.479

High

417856

NPM
Nucleophosmin

1

7

Small-scale

0.479

High

431439

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.479

High

436664

HS90B
Heat shock protein HSP 90-beta

1

3

Small-scale

0.479

High

436675

PTBP1
Polypyrimidine tract-binding protein 1

1

5

Small-scale

0.479

High

436680

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.479

High

436683

YAP1
Transcriptional coactivator YAP1

1

10

Small-scale

0.479

High

436689

FXR2
RNA-binding protein FXR2

1

5

Small-scale

0.479

High

436693

HSP72
Heat shock-related 70 kDa protein 2

1

2

Small-scale

0.479

High

436694

ACTB
Actin, cytoplasmic 1

1

4

Small-scale

0.479

High

436695

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

Small-scale

0.479

High

436697

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

2

Small-scale

0.479

High

436698

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

1

Small-scale

0.479

High

436699

RACK1
Small ribosomal subunit protein RACK1

1

3

Small-scale

0.479

High

436700

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.479

High

436703

ILF3
Interleukin enhancer-binding factor 3

1

7

Small-scale

0.479

High

436704

TRI32
E3 ubiquitin-protein ligase TRIM32

1

11

Small-scale

0.479

High

436706

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

3

Small-scale

0.479

High

436707

SMAD4
Mothers against decapentaplegic homolog 4

1

9

Small-scale

0.479

High

436708

TBB3
Tubulin beta-3 chain

1

3

Small-scale

0.479

High

436711

ASPP2
Apoptosis-stimulating of p53 protein 2

1

6

Small-scale

0.479

High

436714

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

1

Small-scale

0.479

High

436715

IMB1
Importin subunit beta-1

1

13

Small-scale

0.479

High

436716

SMAD2
Mothers against decapentaplegic homolog 2

1

9

Small-scale

0.479

High

436720

K2C79
Keratin, type II cytoskeletal 79

1

4

Small-scale

0.479

High

436725

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

2

Small-scale

0.479

High

436732

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

436736

DDX1
ATP-dependent RNA helicase DDX1

1

4

Small-scale

0.479

High

436737

HDAC2
Histone deacetylase 2

1

12

Small-scale

0.479

High

436740

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

Small-scale

0.479

High

436747

PHB2
Prohibitin-2

1

1

Small-scale

0.479

High

436751

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

436754

HDAC6
Histone deacetylase 6

1

13

Small-scale

0.479

High

436756

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

436758

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.479

High

436759

PRP19
Pre-mRNA-processing factor 19

1

5

Small-scale

0.479

High

127699

SAP18
Histone deacetylase complex subunit SAP18

1

0

Small-scale

0.458

High

129110

IFRD1
Interferon-related developmental regulator 1

1

0

Small-scale

0.458

High

168874

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.458

High

436667

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

Small-scale

0.458

High

436670

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.458

High

436676

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.458

High

436684

CAZA2
F-actin-capping protein subunit alpha-2

1

0

Small-scale

0.458

High

436685

CAPZB
F-actin-capping protein subunit beta

1

0

Small-scale

0.458

High

436702

RL6
Large ribosomal subunit protein eL6

1

0

Small-scale

0.458

High

436723

NUFP2
FMR1-interacting protein NUFIP2

1

0

Small-scale

0.458

High

436730

SERB1
SERPINE1 mRNA-binding protein 1

1

0

Small-scale

0.458

High

436755

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.458

High

436761

ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2

1

0

Small-scale

0.458

High

436678

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

436696

1433E
14-3-3 protein epsilon

1

2

Small-scale

0.445

High

436731

CTSR1
Cation channel sperm-associated protein 1

2

0

High-throughput

0.316

High

436691

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.299

High

436729

ALLC
Probable inactive allantoicase

1

0

High-throughput

0.279

Low

436742

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024