HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: RHEB (Q15382)
GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)
Gene: RHEB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	15854902, 15150271, 9001246, 36244648, 19222999
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 184
+	Hs
		373973 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB8A_HUMAN (7-179): 4.93e-85: 251: 29.05
+	Hs
		374007 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1A_HUMAN (4-183): 1.28e-76: 229: 30.27
+	Hs
		374594 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB2B_HUMAN (1-170): 1.32e-76: 229: 30.41
+	Hs
		374003 RAF1_HUMAN (1-648): 0: 652: 100.00		RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78
+	Hs
		374854 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1B_HUMAN (4-173): 8.3e-76: 227: 30.41
+	Hs
		373976 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58
+	Hs
		373983 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP1B_HUMAN (5-184): 2.05e-37: 129: 38.04
+	Hs
		542884 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RHEB_HUMAN (1-184): 7.42e-94: 272: 100.00
+	Hs
		374009 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP1A_HUMAN (5-163): 2.2e-36: 126: 40.85
+	Hs
		374694 RAF1_HUMAN (1-648): 0: 652: 100.00		DIRA2_HUMAN (1-180): 3.09e-33: 119: 38.25
+	Hs
		373597 RAF1_HUMAN (1-648): 0: 652: 100.00		RALA_HUMAN (8-171): 2.87e-31: 114: 35.54
+	Hs
		373577 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP2A_HUMAN (19-183): 6.71e-30: 109: 38.24
+	Hs
		542851 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RAB1A_HUMAN (4-183): 1.28e-76: 229: 30.27
+	Hs
		488650 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78
+	Hs
		542845 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RAP1B_HUMAN (5-184): 2.05e-37: 129: 38.04
+	Hs
		542852 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RAP1A_HUMAN (5-163): 2.2e-36: 126: 40.85
+	Mm
		655977 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		RAP1B_MOUSE (5-184): 2.05e-37: 129: 38.04
+	Dm
		442951 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		RAP1_DROME (5-164): 6.2e-37: 127: 40.00
+	Dm
		332189 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		O96692_DROME (19-166): 1.07e-30: 112: 38.51
+	Hs
		522878 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58