Protein: RAB21
Ras-related protein Rab-21 (EC 3.6.5.2)

Gene: RAB21
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q9UL25

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005768 - endosome
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460534

RABX5
Rab5 GDP/GTP exchange factor

4

20

Small-scale

0.906

High

724528

GDIA
Rab GDP dissociation inhibitor alpha

3

20

High-throughput

0.871

High

894606

GDIB
Rab GDP dissociation inhibitor beta

2

20

High-throughput

0.811

High

1399272

ANR27
Ankyrin repeat domain-containing protein 27

2

9

High-throughput

0.789

High

1447422

ANLN
Anillin

2

6

High-throughput

0.789

High

1209786

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

14

High-throughput

0.737

High

1394326

VSIG2
V-set and immunoglobulin domain-containing protein 2

2

12

High-throughput

0.705

High

664912

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

20

High-throughput

0.691

High

686597

RAE2
Rab proteins geranylgeranyltransferase component A 2

1

20

High-throughput

0.691

High

976650

RB11A
Ras-related protein Rab-11A

1

17

High-throughput

0.691

High

981378

RAB1A
Ras-related protein Rab-1A

1

19

High-throughput

0.691

High

1144897

RABE1
Rab GTPase-binding effector protein 1

1

10

High-throughput

0.691

High

1356549

RAB2B
Ras-related protein Rab-2B

1

20

High-throughput

0.691

High

1432479

E41LB
Band 4.1-like protein 4B

1

7

High-throughput

0.691

High

1461395

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.691

High

1291773

S22AG
Solute carrier family 22 member 16

3

1

High-throughput

0.662

High

1461082

DP13A
DCC-interacting protein 13-alpha

1

16

Small-scale

0.647

High

1295641

MYLK4
Myosin light chain kinase family member 4

1

6

High-throughput

0.618

High

168057

RGS12
Regulator of G-protein signaling 12

1

2

High-throughput

0.618

High

181833

EPHB6
Ephrin type-B receptor 6

1

17

High-throughput

0.618

High

238833

KALRN
Kalirin

1

15

High-throughput

0.618

High

374271

RASN
GTPase NRas

1

19

High-throughput

0.618

High

375006

RASH
GTPase HRas

1

20

High-throughput

0.618

High

376080

RASK
GTPase KRas

1

20

High-throughput

0.618

High

401686

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.618

High

610066

VGFR1
Vascular endothelial growth factor receptor 1

1

10

High-throughput

0.618

High

901095

RAB5C
Ras-related protein Rab-5C

1

18

High-throughput

0.618

High

901667

RAB7A
Ras-related protein Rab-7a

1

19

High-throughput

0.618

High

958047

RAB14
Ras-related protein Rab-14

1

20

High-throughput

0.618

High

1063027

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

High-throughput

0.618

High

1122583

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

14

High-throughput

0.618

High

1163990

DDR2
Discoidin domain-containing receptor 2

1

20

High-throughput

0.618

High

1459272

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.618

High

1461392

RB22A
Ras-related protein Rab-22A

1

20

High-throughput

0.618

High

1438011

FANCE
Fanconi anemia group E protein

2

0

High-throughput

0.602

High

218944

TGON2
Trans-Golgi network integral membrane protein 2

2

6

High-throughput

0.584

High

243264

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.584

High

465691

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.553

High

650481

FGFR3
Fibroblast growth factor receptor 3

1

16

High-throughput

0.553

High

777790

VGFR3
Vascular endothelial growth factor receptor 3

1

10

High-throughput

0.553

High

820772

CEAM6
Cell adhesion molecule CEACAM6

1

6

High-throughput

0.553

High

1256050

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

1434206

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

178856

SCAM1
Secretory carrier-associated membrane protein 1

1

20

High-throughput

0.536

High

178996

SCAM2
Secretory carrier-associated membrane protein 2

1

20

High-throughput

0.536

High

358826

LDHA
L-lactate dehydrogenase A chain

1

4

High-throughput

0.536

High

540745

LAMP1
Lysosome-associated membrane glycoprotein 1

1

17

High-throughput

0.536

High

699248

CALX
Calnexin

1

5

High-throughput

0.536

High

813253

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

5

High-throughput

0.536

High

951511

SC61B
Protein transport protein Sec61 subunit beta

1

4

High-throughput

0.536

High

1066040

VAC14
Protein VAC14 homolog

1

4

High-throughput

0.536

High

1214382

SYT6
Synaptotagmin-6

1

12

High-throughput

0.536

High

1446943

RTN4
Reticulon-4

1

15

High-throughput

0.536

High

1447848

DDX21
Nucleolar RNA helicase 2

1

1

High-throughput

0.536

High

361374

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

608384

EGLN
Endoglin

1

0

High-throughput

0.513

High

1402501

SERC2
Serine incorporator 2

1

0

High-throughput

0.513

High

1413826

FUCO2
Plasma alpha-L-fucosidase

1

0

High-throughput

0.513

High

1432618

GPT
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

1

0

High-throughput

0.513

High

699582

IL1R2
Interleukin-1 receptor type 2

1

6

High-throughput

0.489

High

733467

CCR1
C-C chemokine receptor type 1

1

8

High-throughput

0.489

High

835419

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

2

High-throughput

0.489

High

1438466

LPAR2
Lysophosphatidic acid receptor 2

1

9

High-throughput

0.489

High

125659

LEG9
Galectin-9

1

4

High-throughput

0.479

High

138334

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

6

High-throughput

0.479

High

189035

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.479

High

377776

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

3

High-throughput

0.479

High

380184

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

7

High-throughput

0.479

High

402434

GBA1
Lysosomal acid glucosylceramidase

1

1

High-throughput

0.479

High

404536

GCR
Glucocorticoid receptor

1

11

High-throughput

0.479

High

431935

ITB1
Integrin beta-1

1

6

Small-scale

0.479

High

508818

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

17

High-throughput

0.479

High

547500

DMD
Dystrophin

1

16

High-throughput

0.479

High

659634

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

883365

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

9

High-throughput

0.479

High

922794

CCHL
Holocytochrome c-type synthase

1

1

High-throughput

0.479

High

1014979

ARF1
ADP-ribosylation factor 1

1

20

High-throughput

0.479

High

1049896

1433F
14-3-3 protein eta

1

4

High-throughput

0.479

High

1108269

SQSTM
Sequestosome-1

1

13

High-throughput

0.479

High

1135164

CUL7
Cullin-7

1

8

High-throughput

0.479

High

1154780

VAMP3
Vesicle-associated membrane protein 3

1

20

High-throughput

0.479

High

1155895

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

1178457

CL16A
Protein CLEC16A

1

4

High-throughput

0.479

High

1229759

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1247039

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1259564

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.479

High

1276367

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.479

High

1314563

TM192
Transmembrane protein 192

1

3

High-throughput

0.479

High

1364674

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

1400943

VPS35
Vacuolar protein sorting-associated protein 35

1

3

High-throughput

0.479

High

1431562

VP33B
Vacuolar protein sorting-associated protein 33B

1

15

High-throughput

0.479

High

1433118

CHM4B
Charged multivesicular body protein 4b

1

8

High-throughput

0.479

High

1461394

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

15

Small-scale

0.462

High

407547

K2C1
Keratin, type II cytoskeletal 1

1

0

High-throughput

0.458

High

447568

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

888386

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

927168

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

530553

TAU
Microtubule-associated protein tau

1

18

High-throughput

0.445

High

935276

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

1277289

S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

1

14

High-throughput

0.445

High

590008

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.437

High

696837

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

13

High-throughput

0.437

High

769487

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

879606

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.437

High

965321

WDR5
WD repeat-containing protein 5

1

6

High-throughput

0.437

High

1005235

RNF4
E3 ubiquitin-protein ligase RNF4

1

7

High-throughput

0.437

High

1024923

VIGLN
Vigilin

1

5

High-throughput

0.437

High

1065486

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.437

High

1100523

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.437

High

1276950

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

1291603

HOOK3
Protein Hook homolog 3

1

14

High-throughput

0.437

High

1294287

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.437

High

1334619

RN149
E3 ubiquitin-protein ligase RNF149

1

20

High-throughput

0.437

High

1438825

HES4
Transcription factor HES-4

1

1

High-throughput

0.437

High

1460578

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.437

High

1461393

CLC4E
C-type lectin domain family 4 member E

1

9

High-throughput

0.437

High

1461396

PCDG4
Protocadherin gamma-A4

1

2

High-throughput

0.437

High

1461397

PCDG3
Protocadherin gamma-A3

1

2

High-throughput

0.437

High

255278

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.407

High

841279

CNDD3
Condensin-2 complex subunit D3

1

3

High-throughput

0.407

High

1053085

VMAT2
Synaptic vesicular amine transporter

1

4

High-throughput

0.407

High

1119357

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.407

High

1398021

MF14A
Hippocampus abundant transcript 1 protein

1

19

High-throughput

0.407

High

724216

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

904244

P2RX1
P2X purinoceptor 1

1

0

High-throughput

0.279

Low

1392193

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

1162616

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1357962

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.249

Low

1399016

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

1446091

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.249

Low

1450970

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025