HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	36244648, 37045861
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 551
+	Hs
		374534 RAF1_HUMAN (1-648): 0: 652: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		373905 RAF1_HUMAN (1-648): 0: 652: 100.00		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		374171 RAF1_HUMAN (1-648): 0: 652: 100.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		302235 RAF1_HUMAN (1-648): 0: 652: 100.00		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		373604 RAF1_HUMAN (1-648): 0: 652: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		373932 RAF1_HUMAN (1-648): 0: 652: 100.00		SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05
+	Hs
		374792 RAF1_HUMAN (1-648): 0: 652: 100.00		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		374841 RAF1_HUMAN (1-648): 0: 652: 100.00		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		433371 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		488705 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		488548 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		488793 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		522960 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516342 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		523147 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56