HitPredict

Interactor 1: RPB1 (P04050)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit 1) (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (RNA polymerase II subunit B220)
Gene: RPO21

Interactor 2: RPAB1 (P20434)
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (ABC27) (DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide)
Gene: RPB5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 10393904, 10784442, 16554755, 17179178, 14759368, 10984524, 15610738, 10024884, 16301539, 26787877, 33226341, 37968396, 20494970, 20094031, 21386817, 22056778
Identification Methods two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, anti tag coimmunoprecipitation, tandem affinity purification, ion exchange chromatography, cross-linking study, molecular sieving
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_Rpb1_1~RNA_pol_Rpb5_C, RNA_pol_Rpb1_1~RNA_pol_Rpb5_N, RNA_pol_Rpb1_5~RNA_pol_Rpb5_C, RNA_pol_Rpb1_5~RNA_pol_Rpb5_N
Common GO terms GO:0001055 - RNA polymerase II activity
GO:0001172 - RNA-templated transcription
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005665 - RNA polymerase II, core complex
and 3 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 1733
Sc

1 215
+ Sp
+ At
+ Sc
+ Hs
+ Hv
+ Sc
+ At
+ Hs
+ At
+ At
+ At
+ Hs
+ Bt
+ Hv

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024