Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Interactor 2: APOB (P04114)
Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]
Gene: APOB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 0.60 0.611

The method score is based on:

Property Details
Experiments 39499777, 24447298
Identification Methods proximity labelling technology, nuclear magnetic resonance, surface plasmon resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005769 - early endosome
GO:0005886 - plasma membrane
GO:0008203 - cholesterol metabolic process
GO:0010008 - endosome membrane
GO:0010628 - positive regulation of gene expression
and 8 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 860
Hs

1 4563
+ Hs
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025