Protein: LRP6
Low-density lipoprotein receptor-related protein 6 (LRP-6)

Gene: LRP6
Organism: Homo sapiens
Interactions: 151
UniProt ID: O75581

Gene Ontology (top 5):
GO:0005041 - low-density lipoprotein particle receptor activity
GO:0005102 - signaling receptor binding
GO:0005109 - frizzled binding
GO:0005576 - extracellular region
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

287503

DKK1
Dickkopf-related protein 1

7

8

Small-scale

0.974

High

287602

SOST
Sclerostin

6

6

Small-scale

0.945

High

287502

LRP6
Low-density lipoprotein receptor-related protein 6

3

11

Small-scale

0.847

High

287633

KLK5
Kallikrein-5

2

12

High-throughput

0.811

High

287625

DKK2
Dickkopf-related protein 2

2

8

Small-scale

0.799

High

287513

CATG
Cathepsin G

2

13

High-throughput

0.776

High

181038

AXIN1
Axin-1

8

5

Small-scale

0.746

High

62191

PRS37
Probable inactive serine protease 37

2

20

High-throughput

0.726

High

287533

ETV6
Transcription factor ETV6

5

2

High-throughput

0.714

High

287544

WNT3A
Protein Wnt-3a

5

16

Small-scale

0.709

High

168352

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.691

High

273737

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

6

High-throughput

0.691

High

287512

KLK3
Prostate-specific antigen

1

15

High-throughput

0.691

High

287519

HGF
Hepatocyte growth factor

1

10

High-throughput

0.691

High

287523

KLK2
Kallikrein-2

1

18

High-throughput

0.691

High

287528

CMA1
Chymase

1

16

High-throughput

0.691

High

287547

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

4

High-throughput

0.691

High

287557

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

4

High-throughput

0.691

High

287606

SIRPD
Signal-regulatory protein delta

1

2

High-throughput

0.691

High

287626

BTNL2
Butyrophilin-like protein 2

1

1

High-throughput

0.691

High

287578

CHST9
Carbohydrate sulfotransferase 9

4

1

High-throughput

0.691

High

287540

GSK3B
Glycogen synthase kinase-3 beta

3

3

Small-scale

0.685

High

287588

PAR16
Protein mono-ADP-ribosyltransferase PARP16

3

1

High-throughput

0.667

High

287599

RHES
GTP-binding protein Rhes

3

6

High-throughput

0.667

High

287611

SG196
Protein O-mannose kinase

5

1

High-throughput

0.654

High

287554

CAV1
Caveolin-1

3

2

Small-scale

0.650

High

287539

GSK3A
Glycogen synthase kinase-3 alpha

2

3

Small-scale

0.649

High

287531

PEDF
Pigment epithelium-derived factor

1

2

Small-scale

0.647

High

287601

KREM1
Kremen protein 1

1

9

Small-scale

0.647

High

287537

KC1A
Casein kinase I isoform alpha

2

4

High-throughput

0.628

High

287628

DKKL1
Dickkopf-like protein 1

2

1

High-throughput

0.628

High

287608

KLK15
Kallikrein-15

1

12

High-throughput

0.618

High

274844

LRP5
Low-density lipoprotein receptor-related protein 5

1

11

Small-scale

0.618

High

287563

TAZ
Tafazzin

3

5

High-throughput

0.609

High

287616

RASF1
Ras association domain-containing protein 1

3

1

High-throughput

0.609

High

287584

TF2LY
Homeobox protein TGIF2LY

3

1

High-throughput

0.604

High

287568

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

Small-scale

0.601

High

143721

WN10B
Protein Wnt-10b

2

16

High-throughput

0.601

High

287529

CTNB1
Catenin beta-1

2

3

Small-scale

0.601

High

287632

PRG3
Proteoglycan 3

2

6

High-throughput

0.601

High

287609

FZD8
Frizzled-8

2

5

Small-scale

0.595

High

287550

RHOB
Rho-related GTP-binding protein RhoB

2

13

High-throughput

0.584

High

287624

CKLF
Chemokine-like factor

2

0

High-throughput

0.580

High

287630

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

2

0

Small-scale

0.576

High

287636

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

0

High-throughput

0.576

High

287506

SG1D1
Secretoglobin family 1D member 1

2

3

High-throughput

0.574

High

287605

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

8

High-throughput

0.574

High

287623

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

2

High-throughput

0.574

High

287505

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

287516

CFC1
Cryptic protein

1

2

High-throughput

0.536

High

287517

PRG2
Bone marrow proteoglycan

1

6

High-throughput

0.536

High

287518

EDN3
Endothelin-3

1

3

High-throughput

0.536

High

287522

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.536

High

287553

IL5RA
Interleukin-5 receptor subunit alpha

1

6

High-throughput

0.536

High

287556

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

5

High-throughput

0.536

High

287561

TLR1
Toll-like receptor 1

1

1

High-throughput

0.536

High

287566

NMS
Neuromedin-S

1

2

High-throughput

0.536

High

287574

LYZL1
Lysozyme-like protein 1

1

3

High-throughput

0.536

High

287581

SYT9
Synaptotagmin-9

1

4

High-throughput

0.536

High

287586

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.536

High

287589

KC1AL
Casein kinase I isoform alpha-like

1

4

High-throughput

0.536

High

287596

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

5

High-throughput

0.536

High

287597

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.536

High

287613

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

287617

CBLN4
Cerebellin-4

1

4

High-throughput

0.536

High

287622

P2RX2
P2X purinoceptor 2

1

1

High-throughput

0.536

High

287629

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

8

High-throughput

0.536

High

287615

AT132
Polyamine-transporting ATPase 13A2

1

0

Small-scale

0.518

High

287515

PGFRB
Platelet-derived growth factor receptor beta

1

4

Small-scale

0.515

High

287552

DAB2
Disabled homolog 2

1

20

Small-scale

0.515

High

287572

CAPR2
Caprin-2

1

4

Small-scale

0.515

High

214108

DHH
Desert hedgehog protein

1

0

High-throughput

0.513

High

287598

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

287509

APOB
Apolipoprotein B-100

1

2

Small-scale

0.501

High

287511

WNT1
Proto-oncogene Wnt-1

1

16

Small-scale

0.501

High

287524

MK
Midkine

1

5

Small-scale

0.501

High

287543

WNT3
Proto-oncogene Wnt-3

1

16

Small-scale

0.501

High

258401

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.493

High

191427

SIA8E
Alpha-2,8-sialyltransferase 8E

1

5

High-throughput

0.489

High

224454

PI15
Peptidase inhibitor 15

1

5

High-throughput

0.489

High

287504

CCN6
Cellular communication network factor 6

1

5

High-throughput

0.489

High

287520

CRIS2
Cysteine-rich secretory protein 2

1

5

High-throughput

0.489

High

287542

FCGRN
IgG receptor FcRn large subunit p51

1

5

High-throughput

0.489

High

287562

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

9

High-throughput

0.489

High

287580

PODN
Podocan

1

2

High-throughput

0.489

High

287587

TAFA2
Chemokine-like protein TAFA-2

1

8

High-throughput

0.489

High

287591

ZN383
Zinc finger protein 383

1

13

High-throughput

0.489

High

287603

OVOL2
Transcription factor Ovo-like 2

1

19

High-throughput

0.489

High

287614

B3GA2
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

1

2

High-throughput

0.489

High

287618

GPTC2
G patch domain-containing protein 2

1

1

High-throughput

0.489

High

287621

DNM3B
DNA

1

1

High-throughput

0.489

High

270419

FZD7
Frizzled-7

1

5

Small-scale

0.484

High

178122

NPC1
NPC intracellular cholesterol transporter 1

1

2

Small-scale

0.479

High

217614

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

287507

RASN
GTPase NRas

1

12

High-throughput

0.479

High

287508

RASK
GTPase KRas

1

12

High-throughput

0.479

High

287510

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

287521

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

287525

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.479

High

287526

CCL1
C-C motif chemokine 1

1

2

Small-scale

0.479

High

287527

IBP4
Insulin-like growth factor-binding protein 4

1

4

Small-scale

0.479

High

287530

BASI
Basigin

1

5

High-throughput

0.479

High

287534

WNT5A
Protein Wnt-5a

1

16

Small-scale

0.479

High

287541

PAR2
Proteinase-activated receptor 2

1

1

Small-scale

0.479

High

287545

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

Small-scale

0.479

High

287546

ANTR2
Anthrax toxin receptor 2

1

2

Small-scale

0.479

High

287548

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

287549

RAC3
Ras-related C3 botulinum toxin substrate 3

1

12

High-throughput

0.479

High

287559

FZD5
Frizzled-5

1

5

Small-scale

0.479

High

287600

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.479

High

287604

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.479

High

287610

RHOJ
Rho-related GTP-binding protein RhoJ

1

15

High-throughput

0.479

High

287612

ANTR1
Anthrax toxin receptor 1

1

2

Small-scale

0.479

High

287619

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.479

High

287620

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

287634

TRAF6
TNF receptor-associated factor 6

1

4

Small-scale

0.479

High

287535

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.458

High

287558

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

0

Small-scale

0.458

High

287575

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

287637

EPN1
Epsin-1

1

0

Small-scale

0.458

High

170584

CLGN
Calmegin

1

7

High-throughput

0.445

High

287514

LEG1
Galectin-1

1

14

High-throughput

0.445

High

287538

SL9A3
Sodium/hydrogen exchanger 3

1

5

High-throughput

0.445

High

287551

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.445

High

287560

SL9A5
Sodium/hydrogen exchanger 5

1

5

High-throughput

0.445

High

287564

MICB
MHC class I polypeptide-related sequence B

1

4

High-throughput

0.445

High

287583

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

1

High-throughput

0.445

High

287585

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

4

High-throughput

0.445

High

287593

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

4

High-throughput

0.445

High

287577

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

287582

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

287595

WDR20
WD repeat-containing protein 20

1

1

Small-scale

0.437

High

287536

EAA4
Excitatory amino acid transporter 4

1

0

High-throughput

0.426

High

287555

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.426

High

287579

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.426

High

287592

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.426

High

287631

TRAK1
Trafficking kinesin-binding protein 1

1

0

High-throughput

0.426

High

287571

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

287573

ZNT6
Zinc transporter 6

1

4

High-throughput

0.407

High

287576

CCNI2
Cyclin-I2

1

1

High-throughput

0.407

High

287569

PAPD7
Terminal nucleotidyltransferase 4A

2

0

High-throughput

0.319

High

287565

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

287570

WDR25
WD repeat-containing protein 25

1

0

High-throughput

0.279

Low

287635

AMMR1
Nuclear protein AMMECR1

1

0

Small-scale

0.279

Low

287532

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

287594

WDR48
WD repeat-containing protein 48

1

0

Small-scale

0.249

Low

287567

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.232

Low

287590

MB213
Protein mab-21-like 3

1

0

High-throughput

0.232

Low

287607

NXF5
Nuclear RNA export factor 5

1

0

High-throughput

0.232

Low

287627

CCNL1
Cyclin-L1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025