HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27545878
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 375
+	Hs
		378051 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Rn
		597913 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		ACTB_RAT (1-375): 0: 603: 100.00
+	Rn
		597917 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		ACTG_RAT (1-375): 0: 601: 98.93
+	Rn
		597919 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		ACTS_RAT (2-375): 0: 592: 93.58
+	Rn
		597915 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		ACTA_RAT (2-375): 0: 591: 94.12
+	Rn
		597918 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		ACTH_RAT (2-375): 0: 589: 93.58
+	Hs
		377884 TNFB_HUMAN (58-233): 1.46e-43: 147: 30.06		ACTB_HUMAN (1-375): 0: 603: 100.00