Interactor 1: IL1A (P01583)
Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)
Gene: IL1A
Interactor 2: IL1R1 (P14778)
Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
Gene: IL1R1
Species: Homo sapiens
Source: innatedb
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 1.00 | 0.618 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 8142597 |
| Identification Methods | chromatography technology |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IL1~Ig_2, IL1~Ig_6 |
| Common GO terms | GO:0005576 - extracellular region GO:0006954 - inflammatory response GO:0006955 - immune response GO:0043123 - positive regulation of canonical NF-kappaB signal transduction |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
