Protein: IL1A
Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)

Gene: IL1A
Organism: Homo sapiens
Interactions: 72
UniProt ID: P01583

Gene Ontology (top 5):
GO:0001660 - fever generation
GO:0001819 - positive regulation of cytokine production
GO:0002248 - connective tissue replacement involved in inflammatory response wound healing
GO:0005125 - cytokine activity
GO:0005149 - interleukin-1 receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378474

IL1R2
Interleukin-1 receptor type 2

3

2

Small-scale

0.843

High

378516

S10AD
Protein S100-A13

1

0

Small-scale

0.654

High

124189

HAX1
HCLS1-associated protein X-1

3

0

Small-scale

0.652

High

378476

CASP1
Caspase-1

1

0

Small-scale

0.631

High

378469

IL1R1
Interleukin-1 receptor type 1

1

2

Small-scale

0.618

High

378467

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.614

High

378517

NECD
Necdin

1

0

Small-scale

0.549

High

253573

IMA7
Importin subunit alpha-7

1

0

High-throughput

0.549

High

378478

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.549

High

378489

BPTF
Nucleosome-remodeling factor subunit BPTF

1

2

High-throughput

0.536

High

378511

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.513

High

348845

CLIC3
Chloride intracellular channel protein 3

1

0

High-throughput

0.493

High

138958

BCL9
B-cell CLL/lymphoma 9 protein

1

3

Small-scale

0.479

High

154600

ARI1A
AT-rich interactive domain-containing protein 1A

1

2

Small-scale

0.479

High

161391

KMT2D
Histone-lysine N-methyltransferase 2D

1

2

Small-scale

0.479

High

378471

JUND
Transcription factor JunD

1

1

Small-scale

0.479

High

378473

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

1

Small-scale

0.479

High

378483

ATN1
Atrophin-1

1

2

Small-scale

0.479

High

378488

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

378492

NCOA2
Nuclear receptor coactivator 2

1

3

Small-scale

0.479

High

378496

CRTC2
CREB-regulated transcription coactivator 2

1

2

Small-scale

0.479

High

378498

ARID2
AT-rich interactive domain-containing protein 2

1

1

Small-scale

0.479

High

378500

CO039
Uncharacterized protein C15orf39

1

1

Small-scale

0.479

High

378501

ASXL2
Putative Polycomb group protein ASXL2

1

1

Small-scale

0.479

High

378502

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

Small-scale

0.479

High

378504

BCL9L
B-cell CLL/lymphoma 9-like protein

1

3

Small-scale

0.479

High

378505

I2BP1
Interferon regulatory factor 2-binding protein 1

1

1

Small-scale

0.479

High

378510

KMT2C
Histone-lysine N-methyltransferase 2C

1

2

Small-scale

0.479

High

378512

MAML1
Mastermind-like protein 1

1

3

Small-scale

0.479

High

378515

CIC
Protein capicua homolog

1

1

Small-scale

0.479

High

378519

SP130
Histone deacetylase complex subunit SAP130

1

2

Small-scale

0.479

High

378525

YETS2
YEATS domain-containing protein 2

1

3

Small-scale

0.479

High

378526

SET1B
Histone-lysine N-methyltransferase SETD1B

1

2

Small-scale

0.479

High

378527

KDM3A
Lysine-specific demethylase 3A

1

1

Small-scale

0.479

High

378530

NCOA3
Nuclear receptor coactivator 3

1

3

Small-scale

0.479

High

272593

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

0

Small-scale

0.458

High

378468

MYBB
Myb-related protein B

1

0

Small-scale

0.458

High

378470

ZEP1
Zinc finger protein 40

1

0

Small-scale

0.458

High

378472

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

378475

PSB4
Proteasome subunit beta type-4

1

0

Small-scale

0.458

High

378477

PCY1A
Choline-phosphate cytidylyltransferase A

1

0

Small-scale

0.458

High

378480

NCBP2
Nuclear cap-binding protein subunit 2

1

0

Small-scale

0.458

High

378481

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.458

High

378484

RAB10
Ras-related protein Rab-10

1

0

Small-scale

0.458

High

378485

SRSF2
Serine/arginine-rich splicing factor 2

1

0

Small-scale

0.458

High

378486

FOXK2
Forkhead box protein K2

1

0

Small-scale

0.458

High

378487

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

378491

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

Small-scale

0.458

High

378494

ZFHX3
Zinc finger homeobox protein 3

1

0

Small-scale

0.458

High

378497

BCORL
BCL-6 corepressor-like protein 1

1

0

Small-scale

0.458

High

378503

KHDC4
KH homology domain-containing protein 4

1

0

Small-scale

0.458

High

378506

MGAP
MAX gene-associated protein

1

0

Small-scale

0.458

High

378507

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

Small-scale

0.458

High

378509

SP20H
Transcription factor SPT20 homolog

1

0

Small-scale

0.458

High

378513

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

Small-scale

0.458

High

378518

PDIP3
Polymerase delta-interacting protein 3

1

0

Small-scale

0.458

High

378520

SHRPN
Sharpin

1

0

Small-scale

0.458

High

378521

EPC1
Enhancer of polycomb homolog 1

1

0

Small-scale

0.458

High

378522

NCOA5
Nuclear receptor coactivator 5

1

0

Small-scale

0.458

High

378523

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

Small-scale

0.458

High

378524

TRPS1
Zinc finger transcription factor Trps1

1

0

Small-scale

0.458

High

378529

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

0

Small-scale

0.458

High

378493

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

1

Small-scale

0.437

High

378495

QSER1
Glutamine and serine-rich protein 1

1

3

Small-scale

0.437

High

378482

SMTN
Smoothelin

1

0

Small-scale

0.249

Low

378490

GSE1
Genetic suppressor element 1

1

0

Small-scale

0.249

Low

378499

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

0

Small-scale

0.249

Low

378508

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

Small-scale

0.249

Low

378514

EP400
E1A-binding protein p400

1

0

Small-scale

0.249

Low

378528

CFA20
Cilia- and flagella-associated protein 20

1

0

Small-scale

0.249

Low

378479

GPC3
Glypican-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025