Protein: IL1R2
Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]

Gene: IL1R2
Organism: Homo sapiens
Interactions: 61
UniProt ID: P27930

Gene Ontology (top 5):
GO:0004908 - interleukin-1 receptor activity
GO:0004910 - interleukin-1, type II, blocking receptor activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378474

IL1A
Interleukin-1 alpha

3

2

Small-scale

0.843

High

378549

IL1B
Interleukin-1 beta

3

12

Small-scale

0.827

High

699549

SCRIB
Protein scribble homolog

2

8

High-throughput

0.811

High

699575

LRRC1
Leucine-rich repeat-containing protein 1

2

4

High-throughput

0.811

High

615205

IL1RA
Interleukin-1 receptor antagonist protein

2

9

Small-scale

0.754

High

699553

MICB
MHC class I polypeptide-related sequence B

1

2

High-throughput

0.691

High

133170

QSOX1
Sulfhydryl oxidase 1

2

6

High-throughput

0.628

High

322702

RHBT3
Rho-related BTB domain-containing protein 3

2

16

High-throughput

0.628

High

699546

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

1

High-throughput

0.628

High

699547

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

1

High-throughput

0.628

High

699557

SE6L2
Seizure 6-like protein 2

2

1

High-throughput

0.628

High

699558

DUSTY
Dual serine/threonine and tyrosine protein kinase

2

5

High-throughput

0.628

High

699559

NLRX1
NLR family member X1

2

3

High-throughput

0.628

High

699560

LONP2
Lon protease homolog 2, peroxisomal

2

1

High-throughput

0.628

High

699565

ZNT5
Proton-coupled zinc antiporter SLC30A5

2

2

High-throughput

0.628

High

699566

EXOC6
Exocyst complex component 6

2

1

High-throughput

0.628

High

699567

CIP2A
Protein CIP2A

2

1

High-throughput

0.628

High

699570

RSPRY
RING finger and SPRY domain-containing protein 1

2

5

High-throughput

0.628

High

699584

DYN3
Dynamin-3

2

2

High-throughput

0.628

High

137187

EXOC5
Exocyst complex component 5

2

0

High-throughput

0.602

High

699555

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

2

0

High-throughput

0.602

High

699562

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.602

High

699568

EXOC4
Exocyst complex component 4

2

0

High-throughput

0.602

High

699569

NUD16
U8 snoRNA-decapping enzyme

2

0

High-throughput

0.602

High

699573

EXOC2
Exocyst complex component 2

2

0

High-throughput

0.602

High

699576

TBCD
Tubulin-specific chaperone D

2

0

High-throughput

0.602

High

699580

EXOC1
Exocyst complex component 1

2

0

High-throughput

0.602

High

699583

EXOC7
Exocyst complex component 7

2

0

High-throughput

0.602

High

699586

EXC6B
Exocyst complex component 6B

2

1

High-throughput

0.574

High

699587

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

Small-scale

0.561

High

299941

CBPD
Carboxypeptidase D

1

1

High-throughput

0.536

High

563244

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

699548

PCDH1
Protocadherin-1

1

6

High-throughput

0.536

High

699585

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.536

High

699579

IL1AP
Interleukin-1 receptor accessory protein

1

13

Small-scale

0.515

High

223465

RGS10
Regulator of G-protein signaling 10

1

0

High-throughput

0.513

High

699543

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.513

High

699552

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.513

High

699561

CCD50
Coiled-coil domain-containing protein 50

1

0

High-throughput

0.513

High

699574

MYADM
Myeloid-associated differentiation marker

1

0

High-throughput

0.513

High

699545

SYHM
Histidine--tRNA ligase, mitochondrial

1

2

High-throughput

0.489

High

699551

UBE3C
Ubiquitin-protein ligase E3C

1

5

High-throughput

0.489

High

699556

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.489

High

699564

ATLA2
Atlastin-2

1

1

High-throughput

0.489

High

699578

AT131
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.489

High

699582

RAB21
Ras-related protein Rab-21

1

6

High-throughput

0.489

High

699588

SAR1B
Small COPII coat GTPase SAR1B

1

9

High-throughput

0.489

High

699544

BMI1
Polycomb complex protein BMI-1

1

4

Small-scale

0.437

High

209742

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

2

0

High-throughput

0.328

High

252831

EXOC3
Exocyst complex component 3

2

0

High-throughput

0.328

High

289755

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

2

0

High-throughput

0.328

High

699563

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.328

High

699571

MITOK
Mitochondrial potassium channel

2

0

High-throughput

0.328

High

699581

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

2

0

High-throughput

0.328

High

177517

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.279

Low

183129

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.279

Low

231449

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.279

Low

699550

PAF15
PCNA-associated factor

1

0

High-throughput

0.279

Low

699572

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.279

Low

699577

RTF2
Replication termination factor 2

1

0

High-throughput

0.279

Low

699554

PRR30
Proline-rich protein 30

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025