HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: DESP (P15924)
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene: DSP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	9261168
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001533 - cornified envelope GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0018149 - peptide cross-linking GO:0045109 - intermediate filament organization and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 644 Hs			1 2871
+	Mm
		93550 K22E_MOUSE (152-500): 8.86e-173: 510: 70.20		DESP_MOUSE (1-2820): 0: 791: 94.42
+	Hs
		408995 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		DESP_HUMAN (1-2871): 0: 818: 100.00
+	Hs
		531529 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		DESP_HUMAN (1-2871): 0: 818: 100.00
+	Hs
		359462 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		DESP_HUMAN (1-2871): 0: 818: 100.00
+	Hs
		409080 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33
+	Hs
		444536 K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33		GOGA4_HUMAN (1137-2522): 1.45e-40: 168: 9.60
+	Hs
		408987 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		MYH1_HUMAN (24-969): 1.33e-34: 148: 9.08
+	Hs
		1068595 K2C78_HUMAN (119-543): 1.51e-130: 395: 55.09		PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33
+	Hs
		234174 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		PEPL_HUMAN (1428-2565): 6.62e-28: 126: 14.08
+	Hs
		409211 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		AKAP9_HUMAN (1336-2427): 2.28e-27: 125: 8.91
+	Hs
		409039 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		444531 K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		885274 K2C78_HUMAN (119-543): 1.51e-130: 395: 55.09		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		821662 K2C6C_HUMAN (2-512): 2.69e-78: 261: 62.62		PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33
+	Hs
		885269 K2C73_HUMAN (1-582): 1.37e-90: 292: 51.63		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		318791 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		213934 KRT86_HUMAN (79-558): 5.38e-84: 274: 43.69		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		885321 KRT82_HUMAN (61-575): 4.79e-77: 256: 44.85		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		885251 K2C72_HUMAN (90-496): 1.88e-73: 247: 61.92		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		580127 K2C4_HUMAN (11-505): 1.78e-66: 228: 58.99		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71