Protein: DRA
HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)

Gene: DRA, HLA-DRA
Organism: Homo sapiens
Interactions: 175
UniProt ID: P01903

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001772 - immunological synapse
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002250 - adaptive immune response
GO:0002469 - myeloid dendritic cell antigen processing and presentation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

380262

DMB
HLA class II histocompatibility antigen, DM beta chain

4

18

Small-scale

0.895

High

380295

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

3

18

High-throughput

0.861

High

380238

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

3

18

Small-scale

0.834

High

380242

HG2A
HLA class II histocompatibility antigen gamma chain

2

9

Small-scale

0.789

High

380263

EPHA3
Ephrin type-A receptor 3

2

13

High-throughput

0.789

High

380272

EPHB4
Ephrin type-B receptor 4

2

14

High-throughput

0.789

High

380335

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

2

5

High-throughput

0.789

High

380369

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

2

5

High-throughput

0.789

High

380261

DMA
HLA class II histocompatibility antigen, DM alpha chain

2

18

Small-scale

0.767

High

191197

TLR3
Toll-like receptor 3

1

4

Small-scale

0.724

High

380388

KLK4
Kallikrein-4

2

12

High-throughput

0.705

High

380237

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

19

High-throughput

0.691

High

380239

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

20

High-throughput

0.691

High

380246

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.691

High

380256

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

19

High-throughput

0.691

High

380258

EPHA1
Ephrin type-A receptor 1

1

11

High-throughput

0.691

High

380278

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

18

High-throughput

0.691

High

380311

TM11B
Transmembrane protease serine 11B

1

10

High-throughput

0.691

High

380327

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

3

High-throughput

0.691

High

380376

BTNL2
Butyrophilin-like protein 2

1

11

High-throughput

0.691

High

380375

LCAP
Leucyl-cystinyl aminopeptidase

4

10

High-throughput

0.691

High

380324

SCRB1
Scavenger receptor class B member 1

3

4

High-throughput

0.667

High

380349

CNTP3
Contactin-associated protein-like 3

3

4

High-throughput

0.667

High

380241

C1QB
Complement C1q subcomponent subunit B

1

2

High-throughput

0.618

High

252305

TLR2
Toll-like receptor 2

1

5

Small-scale

0.618

High

380264

C2TA
MHC class II transactivator

1

3

Small-scale

0.618

High

380346

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

6

High-throughput

0.618

High

380268

MA2A2
Alpha-mannosidase 2x

2

3

High-throughput

0.611

High

380343

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

2

11

High-throughput

0.611

High

380357

PACC1
Proton-activated chloride channel

2

1

High-throughput

0.611

High

380363

CHSTC
Carbohydrate sulfotransferase 12

2

9

High-throughput

0.611

High

380367

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

2

1

High-throughput

0.611

High

380383

DD19B
ATP-dependent RNA helicase DDX19B

2

1

High-throughput

0.611

High

380370

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

3

9

High-throughput

0.609

High

276986

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

2

5

High-throughput

0.601

High

380323

MARH1
E3 ubiquitin-protein ligase MARCHF1

2

1

Small-scale

0.595

High

380297

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.585

High

295721

AP1G2
AP-1 complex subunit gamma-like 2

2

0

High-throughput

0.576

High

380240

MBP
Myelin basic protein

1

1

Small-scale

0.575

High

380255

GDC
Solute carrier family 25 member 16

2

11

High-throughput

0.558

High

380319

NETO2
Neuropilin and tolloid-like protein 2

2

5

High-throughput

0.558

High

380333

TECT2
Tectonic-2

2

6

High-throughput

0.558

High

380380

POMT2
Protein O-mannosyl-transferase 2

2

2

High-throughput

0.558

High

380303

TM214
Transmembrane protein 214

2

2

High-throughput

0.549

High

261047

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.536

High

292513

RENR
Renin receptor

1

2

High-throughput

0.536

High

341269

ECEL1
Endothelin-converting enzyme-like 1

1

7

High-throughput

0.536

High

380251

ADT1
ADP/ATP translocase 1

1

8

High-throughput

0.536

High

380252

PERF
Perforin-1

1

1

High-throughput

0.536

High

380265

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

2

High-throughput

0.536

High

380266

SCNNA
Epithelial sodium channel subunit alpha

1

12

High-throughput

0.536

High

380277

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.536

High

380281

NUCB1
Nucleobindin-1

1

2

High-throughput

0.536

High

380282

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

9

High-throughput

0.536

High

380284

S39A6
Zinc transporter ZIP6

1

15

High-throughput

0.536

High

380286

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

8

High-throughput

0.536

High

380288

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

4

High-throughput

0.536

High

380292

SGCB
Beta-sarcoglycan

1

2

High-throughput

0.536

High

380294

T132A
Transmembrane protein 132A

1

1

High-throughput

0.536

High

380296

ZACN
Ligand-gated cation channel ZACN

1

6

High-throughput

0.536

High

380301

AGRF1
Adhesion G-protein coupled receptor F1

1

5

High-throughput

0.536

High

380305

CNNM4
Metal transporter CNNM4

1

9

High-throughput

0.536

High

380308

CHST9
Carbohydrate sulfotransferase 9

1

9

High-throughput

0.536

High

380310

GALT5
Polypeptide N-acetylgalactosaminyltransferase 5

1

9

High-throughput

0.536

High

380316

ABD12
Lysophosphatidylserine lipase ABHD12

1

3

High-throughput

0.536

High

380320

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

1

8

High-throughput

0.536

High

380321

CNNM3
Metal transporter CNNM3

1

9

High-throughput

0.536

High

380326

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

3

High-throughput

0.536

High

380350

ABCA2
ATP-binding cassette sub-family A member 2

1

5

High-throughput

0.536

High

380352

CHST8
Carbohydrate sulfotransferase 8

1

9

High-throughput

0.536

High

380353

SEM6A
Semaphorin-6A

1

10

High-throughput

0.536

High

380354

SEM6B
Semaphorin-6B

1

10

High-throughput

0.536

High

380355

SIA7D
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

1

8

High-throughput

0.536

High

380360

AT132
Polyamine-transporting ATPase 13A2

1

14

High-throughput

0.536

High

380361

ITM2C
Integral membrane protein 2C

1

8

High-throughput

0.536

High

380365

CNNM1
Metal transporter CNNM1

1

9

High-throughput

0.536

High

380366

SEM4G
Semaphorin-4G

1

11

High-throughput

0.536

High

380368

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

4

High-throughput

0.536

High

380378

TM59L
Transmembrane protein 59-like

1

2

High-throughput

0.536

High

380379

TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme

1

10

High-throughput

0.536

High

380381

DSE
Dermatan-sulfate epimerase

1

2

High-throughput

0.536

High

380382

S39AA
Zinc transporter ZIP10

1

15

High-throughput

0.536

High

380384

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

1

8

High-throughput

0.536

High

380389

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

5

High-throughput

0.536

High

380390

AGRG1
Adhesion G-protein coupled receptor G1

1

5

High-throughput

0.536

High

244433

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.513

High

322123

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.513

High

378403

IFNG
Interferon gamma

1

0

High-throughput

0.513

High

380244

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.513

High

380270

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.513

High

380283

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

380306

KCIP4
Kv channel-interacting protein 4

1

0

High-throughput

0.513

High

380318

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

380332

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.513

High

380274

WDR4
tRNA

1

2

High-throughput

0.494

High

49424

TM223
Transmembrane protein 223

1

2

High-throughput

0.489

High

229115

GTPB6
Putative GTP-binding protein 6

1

2

High-throughput

0.489

High

327098

NXPH4
Neurexophilin-4

1

1

High-throughput

0.489

High

380259

COT2
COUP transcription factor 2

1

2

High-throughput

0.489

High

380271

NEK4
Serine/threonine-protein kinase Nek4

1

4

High-throughput

0.489

High

380273

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

3

High-throughput

0.489

High

380279

SSBP2
Single-stranded DNA-binding protein 2

1

3

High-throughput

0.489

High

380293

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

5

High-throughput

0.489

High

380298

MKS3
Meckelin

1

5

High-throughput

0.489

High

380299

TGO1
Transport and Golgi organization protein 1 homolog

1

2

High-throughput

0.489

High

380300

KMCP1
Kidney mitochondrial carrier protein 1

1

8

High-throughput

0.489

High

380302

MYORG
Myogenesis-regulating glycosidase

1

4

High-throughput

0.489

High

380312

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

12

High-throughput

0.489

High

380313

S2542
Mitochondrial coenzyme A transporter SLC25A42

1

11

High-throughput

0.489

High

380317

S2529
Mitochondrial basic amino acids transporter

1

11

High-throughput

0.489

High

380322

S2540
Mitochondrial glutathione transporter SLC25A40

1

13

High-throughput

0.489

High

380330

TTC28
Tetratricopeptide repeat protein 28

1

2

High-throughput

0.489

High

380331

SARAF
Store-operated calcium entry-associated regulatory factor

1

4

High-throughput

0.489

High

380334

MYO19
Unconventional myosin-XIX

1

3

High-throughput

0.489

High

380337

FACR2
Fatty acyl-CoA reductase 2

1

1

High-throughput

0.489

High

380338

CLP1L
Lipid scramblase CLPTM1L

1

1

High-throughput

0.489

High

380339

SFXN2
Sideroflexin-2

1

4

High-throughput

0.489

High

380340

F210A
Protein FAM210A

1

1

High-throughput

0.489

High

380345

S2533
Solute carrier family 25 member 33

1

10

High-throughput

0.489

High

380347

T106C
Transmembrane protein 106C

1

15

High-throughput

0.489

High

380348

SFXN3
Sideroflexin-3

1

4

High-throughput

0.489

High

380356

MTG2
Mitochondrial ribosome-associated GTPase 2

1

3

High-throughput

0.489

High

380359

S38AA
Solute carrier family 38 member 10

1

5

High-throughput

0.489

High

380362

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.489

High

380364

D39U1
Epimerase family protein SDR39U1

1

2

High-throughput

0.489

High

380371

EXTL2
Exostosin-like 2

1

7

High-throughput

0.489

High

380372

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.489

High

380374

SE1L1
Protein sel-1 homolog 1

1

2

High-throughput

0.489

High

380387

RN115
E3 ubiquitin-protein ligase RNF115

1

6

High-throughput

0.489

High

61073

T131L
Transmembrane protein 131-like

1

7

High-throughput

0.479

High

380243

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

8

Small-scale

0.479

High

380245

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

380247

HS90B
Heat shock protein HSP 90-beta

1

7

Small-scale

0.479

High

380248

CD63
CD63 antigen

1

8

Small-scale

0.479

High

380249

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

380250

CD20
B-lymphocyte antigen CD20

1

3

Small-scale

0.479

High

380253

KPYM
Pyruvate kinase PKM

1

3

Small-scale

0.479

High

380260

CD82
CD82 antigen

1

8

Small-scale

0.479

High

380269

ANX11
Annexin A11

1

4

Small-scale

0.479

High

380276

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

380280

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

1

High-throughput

0.479

High

380287

STIM1
Stromal interaction molecule 1

1

3

High-throughput

0.479

High

380351

TOLIP
Toll-interacting protein

1

1

Small-scale

0.479

High

380377

PLXA1
Plexin-A1

1

11

High-throughput

0.479

High

274936

TM127
Transmembrane protein 127

1

0

Small-scale

0.458

High

380358

PKHA2
Pleckstrin homology domain-containing family A member 2

1

0

Small-scale

0.458

High

380290

VAS1
V-type proton ATPase subunit S1

1

1

High-throughput

0.445

High

380291

EXT1
Exostosin-1

1

7

High-throughput

0.445

High

380386

AP3M1
AP-3 complex subunit mu-1

1

3

High-throughput

0.445

High

380307

BRWD3
Bromodomain and WD repeat-containing protein 3

1

2

High-throughput

0.437

High

380275

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.426

High

293016

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.407

High

380309

ARMX2
Armadillo repeat-containing X-linked protein 2

1

1

High-throughput

0.407

High

380341

CNT3B
Contactin-associated protein-like 3B

1

4

High-throughput

0.407

High

380342

MIA2
Melanoma inhibitory activity protein 2

1

3

High-throughput

0.407

High

67346

RTL8C
Retrotransposon Gag-like protein 8C

1

0

High-throughput

0.279

Low

238341

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.279

Low

283173

ERLN1
Erlin-1

1

0

High-throughput

0.279

Low

346753

CER1
Cerberus

1

0

High-throughput

0.279

Low

380257

TBP
TATA-box-binding protein

1

0

High-throughput

0.279

Low

380285

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

380289

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.279

Low

380304

CC033
Protein C3orf33

1

0

High-throughput

0.279

Low

380314

MICU2
Calcium uptake protein 2, mitochondrial

1

0

High-throughput

0.279

Low

380315

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

380328

NXPE3
NXPE family member 3

1

0

High-throughput

0.279

Low

380329

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.279

Low

380336

SRAC1
Protein SERAC1

1

0

High-throughput

0.279

Low

380344

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.279

Low

380373

FA8A1
Protein FAM8A1

1

0

High-throughput

0.279

Low

380385

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

380325

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.269

Low

380254

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.249

Low

380267

RFX5
DNA-binding protein RFX5

1

0

Small-scale

0.249

Low

318941

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025