HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27591049
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0050728 - negative regulation of inflammatory response
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 644 Hs			1 956
+	Hs
		409246 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		444557 K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1231037 K2C78_HUMAN (119-543): 1.51e-130: 395: 55.09		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1343331 KRT84_HUMAN (3-644): 8.54e-97: 311: 44.36		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		531636 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		380523 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1110348 K2C71_HUMAN (1-574): 1.29e-78: 261: 52.09		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		359537 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1062069 K2C72_HUMAN (90-496): 1.88e-73: 247: 61.92		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1192468 K2C1B_HUMAN (62-511): 4.84e-63: 220: 64.00		CYLD_HUMAN (1-956): 0: 1872: 100.00