HitPredict

Interactor 1: EGFR (P04412)
Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) (Drosophila relative of ERBB) (Gurken receptor) (Protein torpedo)
Gene: EGFR

Interactor 2: Q9VK54 (Q9VK54)
Kekkon 1, isoform B (Kekkon 1, isoform C)
Gene: kek1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.933

Property	Details
Experiments	23827685, 10102272, 12900463, 15020418, 15166146, 15020419
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1426 Dm			1 880
+	Dm
		382204 EGFR_DROME (1-1426): 0: 1427: 100.00		P91643_DROME (1-880): 0: 548: 99.89
+	Hs
		1070977 ERBB4_HUMAN (415-1408): 2.11e-156: 509: 25.96		LRIG3_HUMAN (1-879): 8.71e-83: 290: 12.11
+	Hs
		1070999 ERBB4_HUMAN (415-1408): 2.11e-156: 509: 25.96		LRIG1_HUMAN (104-714): 3.61e-53: 203: 12.89
+	Hs
		434263 RET_HUMAN (647-1289): 1.55e-125: 420: 19.81		LRIG1_HUMAN (104-714): 3.61e-53: 203: 12.89
+	Mm
		724165 RET_MOUSE (642-1289): 3.22e-125: 419: 19.44		LRIG1_MOUSE (104-820): 4.32e-51: 196: 12.47
+	Hs
		299548 RET_HUMAN (647-1289): 1.55e-125: 420: 19.81		LRIG2_HUMAN (90-827): 8.26e-45: 177: 12.49
+	Hs
		259492 FGFR1_HUMAN (763-1251): 9.7e-130: 423: 23.88		LRRN2_HUMAN (21-518): 3.12e-42: 167: 13.81
+	Hs
		338583 EGFR_HUMAN (100-413): 3.59e-29: 129: 19.49		LRIG3_HUMAN (1-879): 8.71e-83: 290: 12.11
+	Hs
		383860 ERBB2_HUMAN (111-415): 5.1e-23: 109: 21.02		LRIG3_HUMAN (1-879): 8.71e-83: 290: 12.11
+	Hs
		601975 ERBB3_HUMAN (85-429): 2.48e-31: 136: 19.85		LRIG1_HUMAN (104-714): 3.61e-53: 203: 12.89
+	Hs
		338841 EGFR_HUMAN (100-413): 3.59e-29: 129: 19.49		LRIG1_HUMAN (104-714): 3.61e-53: 203: 12.89
+	Mm
		936212 EGFR_MOUSE (100-412): 1.08e-27: 124: 20.18		LRIG1_MOUSE (104-820): 4.32e-51: 196: 12.47
+	Hs
		383933 ERBB2_HUMAN (111-415): 5.1e-23: 109: 21.02		LRIG1_HUMAN (104-714): 3.61e-53: 203: 12.89
+	Hs
		338833 EGFR_HUMAN (100-413): 3.59e-29: 129: 19.49		LIGO1_HUMAN (87-515): 1.83e-47: 181: 15.65
+	Hs
		299545 EGFR_HUMAN (100-413): 3.59e-29: 129: 19.49		LRIG2_HUMAN (90-827): 8.26e-45: 177: 12.49
+	Mm
		964570 EGFR_MOUSE (100-412): 1.08e-27: 124: 20.18		LIGO1_MOUSE (87-526): 3.04e-46: 177: 16.32
+	Dm
		219802 ABL_DROME (917-1190): 1.04e-50: 199: 41.88		O44924_DROME (251-778): 2.47e-10: 66.9: 10.11