HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: AT2A2 (P16615)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Gene: ATP2A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	24189400
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 1042
+	Hs
		383917 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		AT2A3_HUMAN (1-997): 0: 956: 76.85
+	Hs
		337885 EGFR_HUMAN (16-1253): 0: 1070: 48.40		AT2A2_HUMAN (1-1042): 0: 1060: 100.00
+	Hs
		383521 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		AT1A1_HUMAN (3-997): 0: 797: 26.72
+	Hs
		337753 EGFR_HUMAN (16-1253): 0: 1070: 48.40		AT1A1_HUMAN (3-997): 0: 797: 26.72
+	Hs
		337946 EGFR_HUMAN (16-1253): 0: 1070: 48.40		AT2B4_HUMAN (3-1028): 0: 762: 25.75
+	Rn
		416146 INSR_RAT (357-634): 2.53e-16: 87.2: 19.87		AT1A1_RAT (3-997): 0: 798: 26.82