Protein: THDH
Threonine dehydratase, mitochondrial (EC 4.3.1.19) (Threonine deaminase)

Gene: THDH, ILV1
Organism: Saccharomyces cerevisiae S288C
Interactions: 116
UniProt ID: P00927

Gene Ontology (top 5):
GO:0004794 - threonine deaminase activity
GO:0005739 - mitochondrion
GO:0006567 - L-threonine catabolic process
GO:0009097 - isoleucine biosynthetic process
GO:0030170 - pyridoxal phosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

368096

THDH
Threonine dehydratase, mitochondrial

2

19

High-throughput

0.775

High

368127

HSP60
Heat shock protein 60, mitochondrial

4

3

High-throughput

0.687

High

368125

HSC82
ATP-dependent molecular chaperone HSC82

3

11

High-throughput

0.643

High

368131

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

20

High-throughput

0.618

High

368119

HSP71
Heat shock protein SSA1

4

8

High-throughput

0.608

High

368156

EF1G2
Elongation factor 1-gamma 2

2

0

High-throughput

0.595

High

368108

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

2

1

High-throughput

0.571

High

368170

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

3

High-throughput

0.571

High

368204

RUVB2
RuvB-like protein 2

2

7

High-throughput

0.558

High

368099

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.536

High

368184

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

368144

HS104
Heat shock protein 104

2

7

Small-scale

0.533

High

358920

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.515

High

359391

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.515

High

368157

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

368148

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.508

High

368105

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.493

High

368100

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

3

High-throughput

0.489

High

368109

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.489

High

368172

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.489

High

368112

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.479

High

368116

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

368126

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

368129

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

368136

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

368139

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

368141

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.479

High

368154

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.479

High

368166

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

368169

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

3

High-throughput

0.479

High

368178

TOM22
Mitochondrial import receptor subunit TOM22

1

1

High-throughput

0.479

High

368181

ALAT1
Alanine aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

368186

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

368189

ESP1
Separin

1

1

High-throughput

0.479

High

368135

CSM1
Monopolin complex subunit CSM1

1

1

High-throughput

0.464

High

368146

IMB3
Importin subunit beta-3

1

2

High-throughput

0.464

High

368206

MTR10
mRNA transport regulator MTR10

1

1

High-throughput

0.464

High

368145

OAC1
Mitochondrial oxaloacetate transport protein

1

0

High-throughput

0.458

High

368151

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

368158

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

368190

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

368195

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

368117

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.457

High

368107

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

368120

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

368124

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.445

High

368180

RL4P
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.445

High

368121

MITF2
Mitochondrial translation factor 2

1

0

High-throughput

0.438

High

149445

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.437

High

368097

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

368098

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.437

High

368101

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

368102

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

368103

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.437

High

368104

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

368110

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

368111

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

368118

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.437

High

368123

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

368128

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.437

High

368130

SIS1
Protein SIS1

1

4

High-throughput

0.437

High

368132

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

368138

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

368142

URA7
CTP synthase 1

1

1

High-throughput

0.437

High

368143

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

368152

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

368153

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

368155

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

368162

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

368168

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

368177

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

368179

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.437

High

368182

HST2
NAD-dependent protein deacetylase HST2

1

1

High-throughput

0.437

High

368187

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

368191

RUVB1
RuvB-like protein 1

1

7

High-throughput

0.437

High

368193

SIZ1
E3 SUMO-protein ligase SIZ1

1

3

High-throughput

0.437

High

368197

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.437

High

368198

SUB2
ATP-dependent RNA helicase SUB2

1

1

High-throughput

0.437

High

368200

MCA1
Metacaspase-1

1

1

High-throughput

0.437

High

368201

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

368140

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

368205

GLT1
Glutamate synthase [NADH]

1

0

High-throughput

0.426

High

364197

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.407

High

368122

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.407

High

368134

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.407

High

368149

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.407

High

368164

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.407

High

368167

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.407

High

368174

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

368133

RAD51
DNA repair protein RAD51

2

0

High-throughput

0.324

High

368188

MUK1
Protein MUK1

2

0

High-throughput

0.307

High

368160

TOS1
Probable circularly permuted 1,3-beta-glucanase TOS1

2

0

High-throughput

0.307

High

368175

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.282

High

368185

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

368163

DBP8
ATP-dependent RNA helicase DBP8

1

0

High-throughput

0.279

Low

368173

SA155
SIT4-associating protein SAP155

1

0

High-throughput

0.279

Low

368106

CDC31
Cell division control protein 31

1

0

High-throughput

0.269

Low

368161

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.265

Low

368196

BCP1
Protein BCP1

1

0

High-throughput

0.265

Low

368202

NBP2
NAP1-binding protein 2

1

0

High-throughput

0.251

Low

368113

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

368114

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

368115

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

368137

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

368147

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

368159

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.249

Low

368165

SBE22
Protein SBE22

1

0

High-throughput

0.249

Low

368171

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

368176

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

368183

ATP23
Mitochondrial inner membrane protease ATP23

1

0

High-throughput

0.249

Low

368203

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.249

Low

368150

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

High-throughput

0.238

Low

368194

MYO5
Myosin-5

1

0

High-throughput

0.238

Low

368199

ADY3
Accumulates dyads protein 3

1

0

High-throughput

0.238

Low

368192

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025